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VMAT Concurrent Cisplatin Plus Nab-paclitaxel for Local Advanced Cervical Cancer

Cervical Cancer Clinical Trial

Official title:
Study of Radiation Therapy With Concomitant Nab-paclitaxel and Cisplatin Chemotherapy in Patients With Locally Advanced Cervical Cancer

Clinical Trial Summary

This is a single arm, open-lable Phase I clinical trial. Eligible patients will have Histologically proven stage IB2-IVA cervical cancer. We hypothesize that Nab-paclitaxel in combination with cisplatin and radiotherapy may have anti-tumor activity in patients with cervical cancer. Nab-paclitaxel has not previously been combined with conventional RT-CT to treat cervical cancer.

Clinical Trial Description

During the phase I study, patients will receive radiation therapy to pelvis (50.4 Gy in 28fractions), and followed by HDR intracavitary (30Gy in 5 fractions) brachytherapy. Concurrent chemotherapy was administered with weekly cisplatin (40 mg/m^2) and an escalating dose of weekly Nab-paclitaxel starting at 10 mg/m^2 up to 70 mg/m^2. Chemotherapy agents were administered in escalating doses to cohorts of three patients at each dose level. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04017377
Study type Interventional
Source Peking University Third Hospital
Contact Junjie Wang, MD, PhD
Phone 13701076310
Email junjiewang_edu@sina.cn
Status Recruiting
Phase N/A
Start date September 1, 2019
Completion date July 15, 2020
View Details
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