Cervical Cancer Clinical Trial
Radiation therapy (RT) is used as an effective local treatment modality to inhibit cell
proliferation, induce cell death and suppress tumor growth. To improve the treatment
outcome, in terms of both locoregional control and survival, the concurrent use of
chemotherapy during radiation therapy (CCRT) is now the standard treatment for various
malignancies, especially locally advanced cancers. Among the drugs used to enhance RT
effect, 5-fluorouracil (5-FU) is one of the most commonly used chemotherapeutic agents of
CCRT.
In the past, RT was solely used as a local treatment and its effect was estimated by local
effect model. However, growing evidence shows that irradiation has direct DNA
damage-dependent effects as well as sending signals to neighboring cells. Recently, we
reported that abdominal irradiation could significantly modulate the systemic
pharmacokinetics of 5-FU at 0.5 Gy, off-target area in clinical practice, and at 2 Gy, the
daily treatment dose for target treatment in an experimental rat model. Additionally, the
results from a clinical investigation showed that colorectal cancer patients with lower AUC
of 5-FU during adjuvant chemotherapy had lower disease-free survival. Taken together, these
lines of evidence support the importance and necessity to search for the mediators
responsible for the unexpected effect of local RT on systemic pharmacokinetics of
chemotherapeutic agents, such as 5-FU.
In the present study, the investigators investigated whether the phenomena and mechanism of
RT-PK is a fact for different anticancer drugs in human.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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