Cervical Cancer Clinical Trial
Official title:
MR-PET Guided Biologically Optimised Interstitial Brachytherapy for Postoperative Recurrent Cervical Cancers
The proposed two stage study will evaluate patterns of local recurrence after EBRT and
brachytherapy in spatial reference to baseline functional MRI and FLT/F-Miso PET scan in
patients undergoing chemoradiotherapy for postoperative recurrences of cervical cancer. The
first stage of the study will focus on developing MR guided interstitial brachytherapy and
validating the concept of high risk gross tumor volume (on the basis of functional imaging
features).
The second stage thereafter will focus on developing biologically modulated interstitial
brachytherapy.
In the proposed two staged study the investigators intend to prospectively evaluate and
validate concept of HRGTV and develop technique of biologically dose modulated brachytherapy.
The demonstration of technical feasibility and clinical safety of biologically modulated
image guided radiotherapy in this pilot study for may pave the way for improving local
control in patients with postoperative recurrences.
Aims
Stage I
Aim 1: To spatially characterize biologically heterogenous subvolumes within the gross tumor
through multimodality (18 F-Miso/FLT/Functional MR) image fusion.
Aim 2: To evaluate post external beam radiotherapy (EBRT) response in spatial reference to
biological heterogeneous sub-volumes on imaging.
Stage II:
Aim 3: To evaluate technical feasibility of delivering dose modulated biologically optimized
interstitial brachytherapy.
Aim 4: To evaluate acute and late toxicity and quality of life associated with biologically
optimized brachytherapy
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