Cervical Cancer Clinical Trial
Official title:
Phase III Randomized Trial of Cisplatin/Paclitaxel Versus Cisplatin/Gemcitabine in Recurrent, Persistent or Metastatic Carcinoma of the Cervix
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die. Combining more than one drug may kill more tumor cells. It is
not yet known whether cisplatin is more effective when combined with paclitaxel or
gemcitabine in treating cervical cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of cisplatin combined with
paclitaxel to that of cisplatin combined with gemcitabine in treating women who have
recurrent, persistent, or metastatic cervical cancer.
OBJECTIVES:
- Compare the overall survival, progression-free survival, and objective response rate
(confirmed and unconfirmed, complete and partial) of patients with recurrent,
persistent, or metastatic cervical cancer treated with cisplatin and paclitaxel vs
cisplatin and gemcitabine.
- Compare the toxicity of these regimens in these patients.
OUTLINE: This is a randomized, multicenter study. Patients are stratified according to
disease status at study entry (metastatic vs recurrent vs persistent), prior cisplatin as a
radiosensitizer (yes vs no), and extent of disease (confined to pelvis vs extrapelvic
disease). Patients are randomized to 1 of 2 treatment arms.
- Arm I: Patients receive paclitaxel IV over 24 hours on day 1 and cisplatin IV over 2
hours on day 2.
- Arm II:Patients receive gemcitabine IV over 30 minutes on days 1 and 8 and cisplatin IV
over 2 hours on day 1.
In both arms, treatment repeats every 21 days for up to 6 courses in the absence of disease
progression or unacceptable toxicity.
Patients are followed every 3 months for 2 years and then annually for 3 years.
PROJECTED ACCRUAL: A total of 500 patients (250 per treatment arm) will be accrued for this
study within 4 years.
;
Allocation: Randomized, Primary Purpose: Treatment
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