Orientation Agnosia: Clinical and Anatomical Study

Cerebrovascular Disorders Clinical Trial

— AGNORIENT  

Official title:

Orientation Agnosia: Neuropsychological Evaluation, Associated Symptoms, Clinical and Anatomical Correlations

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01304576
• Other study ID #: 2009/126/HP
• Secondary ID: number ID RCB 20
• Status: Completed
• Phase: N/A
• First received: August 23, 2010
• Last updated: September 1, 2014
• Start date: September 2010
• Est. completion date: December 2013

Study information

• Verified date: September 2014
• Source: University Hospital, Rouen
• Contact: n/a
• Is FDA regulated: No
• Health authority: France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)
• Study type: Interventional

Clinical Trial Summary

The area of the brain responsible of visuospatial processing data and more specifically the orientation of an object or image is located in parietal lobe, especially on the right side. A dysfunction of this region would result in a disorder of recognition of the orientation of objects and images that the investigators call orientation agnosia. Several isolated cases are reported in the literature but to the investigators knowledge deficit has never been systematically searched, or put into perspective compared to other neuropsychological deficits. Moreover, the precise location of the lesion responsible for such a disorder remains uncertain. The objectives of this study are (1) detect the existence of orientation agnosia in case of right parietal lesion, and (2) to improve the understanding of such a deficit allowing better management of this disorder.

Description:

Idem

Recruitment information / eligibility

• Status: Completed
• Enrollment: 34
• Est. completion date: December 2013
• Est. primary completion date: December 2013
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• age between 18 and 80 years

• french language

• right parietal lesion on cerebral imaging (CT-scan is sufficient), including stroke,arterial malformation, isolated tumoral lesion

• informed consent

Exclusion Criteria:

• previous neurological history except non complicated migraine and stabilized epilepsia without seizure since 5 years

• previous psychiatric history except depression without hospitalization > one week or anxiety with maximum one anxiolytic treatment

• drug or alcohol abuse

• severe cranial traumatism

• other severe chronic pathology

• psychotropic medication other than a hypnotic or an anxiolytic at low doses without dose modification for at least one month

• visual impairment

• motor or sensory deficit sufficient to render impossible neuropsychological tests

• patient without judicial or administrative liberty

• measure of legal protection or no capable to express their consent

• pregnancy or breastfeeding

Study Design

Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Screening

Related Conditions & MeSH terms

• Brain Lesions
• Cerebrovascular Disorders

Intervention

Behavioral:
• Neuropsychological testing
Experimental test about orientation agnosia and standard neuropsychological tests.

Other:
• MRI
Cerebral MRI

Locations

Country	Name	City	State
France	CHU de Rouen - Hôpitaux de Rouen	Rouen	Haute-Normandie

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Rouen

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	orientation agnosia evaluation	orientation agnosia test	1 week to 6 months (average)	No
Secondary	associated clinical symptoms especially apraxia		1 week to 6 months (average)	No