Clinical Trials Logo

Clinical Trial Summary

Postoperative neurocognitive disorders (NCD) are of high priority in perioperative management. The risk of suffering from NCD after surgery may be increased due to perioperative impairment of cerebrovascular autoregulation and thereby inadequate cerebral perfusion. Cerebrovascular autoregulation refers to the ability of cerebral arterioles to ensure constant cerebral blood flow independently of fluctuations in systemic blood pressure. Cerebrovascular autoregulation can be measured based on mean arterial pressure (MAP) and a surrogate for cerebral blood flow using the correlation method. Until today, measurement of cerebral blood flow velocity assessed with transcranial Doppler sonography (TCD) is most commonly used as a non-invasive surrogate for cerebral blood flow. Alternatively, cerebral oxygenation measured with near-infrared spectroscopy (NIRS) can be used as another surrogate. The study includes three substudies: 1. To compare NIRS and TCD for the assessment of perioperative cerebrovascular autoregulation in patients undergoing major non-cardiac surgery with an increased risk of bleeding. 2. To compare MAP for optimal cerebrovascular autoregulation before induction of general anesthesia with MAP for optimal cerebrovascular autoregulation during or after general anesthesia. 3. To analyze the association between the time-weighted average MAP below the MAP for optimal cerebrovascular autoregulation and postoperative NCD.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04978558
Study type Observational
Source Universitätsklinikum Hamburg-Eppendorf
Contact Marlene Fischer, MD, PhD
Phone +4915222827500
Email mar.fischer@uke.de
Status Not yet recruiting
Phase
Start date August 2021
Completion date February 2023

See also
  Status Clinical Trial Phase
Completed NCT03704519 - Imaging Study to Compare Effects of Darolutamide and Enzalutamide With Respect to Placebo on the Blood Flow in the Brain in Healthy Male Volunteers. Phase 1
Recruiting NCT05920759 - Sex-specific Effect of Restricted Sleep on Brain Health N/A
Recruiting NCT03512613 - A Pilot Study- Monitoring Cerebral Blood Flow in Neonates With Congenital Heart Defects
Recruiting NCT05864950 - Brain Blood Flow Responses During Exercise N/A
Completed NCT02982122 - CPPopt Guided Therapy: Assessment of Target Effectiveness N/A
Completed NCT02653638 - Blood Brain Flow and Exercise Early Phase 1
Completed NCT03732651 - The Impact of Non-pulsatile Blood Flow on CO2-Reactivity N/A
Completed NCT03278769 - Ventilator Settings on Patients With Acute Brain Injury N/A
Recruiting NCT05893407 - Brain PERfusion Evaluation by Contrast-Enhanced UltraSound
Recruiting NCT05051397 - CO2 Modulation in Endovascular Thrombectomy for Acute Ischemic Stroke Phase 2
Completed NCT03484104 - Cerebral Perfusion in Hypothermic Circulatory Arrest
Completed NCT03816072 - Quantification of Dynamic and Static Cerebral Autoregulation (CA) Under Anaesthesia N/A
Terminated NCT04234009 - Lifestyle and Brain Vascular Function N/A
Recruiting NCT06368635 - The Cerebral Microcirculation Diseases and Coronary Microcirculation Disease Study
Recruiting NCT05394935 - The Effects of High-intensity and Moderate-intensity Exercise on Polycystic Ovary Syndrome N/A
Completed NCT01169662 - Effects of Dietary Nitrate From Vegetable/Fruit Juice on Cerebral Blood Flow Parameters Phase 4
Recruiting NCT03591523 - Blood Flow Measurement Using Quantitative Magnetic Resonance Angiography and Duplex Sonography
Recruiting NCT04391465 - Assessment of the Relationship Between Cerebral Blood Flow and Heart Rate N/A
Completed NCT03953391 - The Effect of Tea Breaks on Cerebrovascular Perfusion During Desk Work N/A
Recruiting NCT02748447 - Automated Adjustment of Inspired Oxygen to Maintaining Regional Cerebral Oxygenation in Preterm Infants on Respiratory Support N/A