Cerebrovascular Circulation Clinical Trial
Official title:
Blood Flow Measurement in Cervical and Cerebral Arteries Using Quantitative Magnetic Resonance Angiography and Cervical and Transcranial Duplex Sonography
The aim of the study is to assess the correlation of blood flow measurement in cervical and intracranial arteries between quantitative magnetic resonance angiography (qMRA) and duplex sonography (DS) and inter-/intra-investigators reliability of both methods in common clinical practice. A total of 21 subjects indicated to qMRA or DS for suspicion of cervical or intracranial vascular pathology will be included. All patients will undergo qMRA and DS of the cervical and intracranial arteries with measurement of blood flow in bilateral common carotid artery (CCA), internal carotid artery in proximal part distally to carotid bulb (ICA) and in distal carotid siphon (ICA-siphon), external carotid artery (ECA), vertebral artery in V2 (V2-VA) and V4 (V4-VA) segments, middle cerebral artery (MCA), anterior cerebral artery in pre-communicant (ACA1) and post-communicant (ACA2) part, posterior cerebral artery in pre-communicant (PCA1) and post-communicant (PCA2) part and basilar artery (BA) the cerebral artery. Correlations between measurements will be evaluated using Spearman's correlation coefficient or kappa coefficient and inter-class correlation coefficient (ICC).
Introduction: Measurement of blood flow in cervical and cerebral arteries is important not
only for accurate diagnosis of neurovascular diseases but also for refinement of the
indication of invasive treatment. Quantitative MR angiography (qMRA) with NOVA flow analysis
system and duplex sonography (DS; duplex sonography of cervical arteries and transcranial
color-coded duplex sonography) are non-invasive diagnostics methods which could be used for
measurement of blood flow in cervical and intracranial arteries.
Aim: The aim of the study is to assess the correlation of blood flow measurement in cervical
and intracranial arteries between qMRA and DS in common clinical practice. The secondary aims
are to assess the inter-investigator and intra-investigator correlations of both qMRA and DS
in blood flow measurement.
Methods: A total of 21 subjects indicated to qMRA or DS for suspicion of cervical or
intracranial vascular pathology will be included.
Inclusion criteria: male or female; age 25 - 70 years; signed informed consent. Exclusion
criteria: contraindication to magnetic resonance; uncontrolled involuntary movements; other
condition preventing long-term quiet lying.
All patients will undergo qMRA and DS of the cervical and intracranial arteries within 2
hours. The NOVA flow analysis system will calculate blood flow in individual segments. In DS,
angle corrected blood flow velocities (peak systolic velocity - PSV, end-diastolic velocity -
EDV, mean velocity - Vmean) will be measured in individual segments with measurement of
arterial in the B-Mode or Color Mode with automatic calculation of blood flow.
The blood flow will be assessed in the following arterial segments: bilateral common carotid
artery (CCA), internal carotid artery in proximal part distally to carotid bulb (ICA) and in
distal carotid siphon (ICA-siphon), external carotid artery (ECA), vertebral artery in V2
(V2-VA) and V4 (V4-VA) segments, middle cerebral artery (MCA), anterior cerebral artery in
pre-communicant (ACA1) and post-communicant (ACA2) part, posterior cerebral artery in
pre-communicant (PCA1) and post-communicant (PCA2) part and basilar artery (BA) the cerebral
artery.
At least 2 patients will undergo qMRA and DS performed by the same investigators twice in the
time interval of 2 - 10 days and DS will be performed in all patients by 2 sonographers using
2 different machines for assessment of inter-investigator and intra-investigator reliability.
All investigators will be blinded to the diagnosis and measurement performed using other
diagnostics method.
In all patients will be collecting following data: blood pressure, weight, height, age,
gender, time of examination Statistics: Correlations between measurements will be evaluated
using Spearman's correlation coefficient or kappa coefficient and inter-class correlation
coefficient (ICC).
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03704519 -
Imaging Study to Compare Effects of Darolutamide and Enzalutamide With Respect to Placebo on the Blood Flow in the Brain in Healthy Male Volunteers.
|
Phase 1 | |
Recruiting |
NCT05920759 -
Sex-specific Effect of Restricted Sleep on Brain Health
|
N/A | |
Recruiting |
NCT03512613 -
A Pilot Study- Monitoring Cerebral Blood Flow in Neonates With Congenital Heart Defects
|
||
Recruiting |
NCT05864950 -
Brain Blood Flow Responses During Exercise
|
N/A | |
Completed |
NCT02982122 -
CPPopt Guided Therapy: Assessment of Target Effectiveness
|
N/A | |
Completed |
NCT02653638 -
Blood Brain Flow and Exercise
|
Early Phase 1 | |
Completed |
NCT03732651 -
The Impact of Non-pulsatile Blood Flow on CO2-Reactivity
|
N/A | |
Completed |
NCT03278769 -
Ventilator Settings on Patients With Acute Brain Injury
|
N/A | |
Recruiting |
NCT05893407 -
Brain PERfusion Evaluation by Contrast-Enhanced UltraSound
|
||
Recruiting |
NCT05051397 -
CO2 Modulation in Endovascular Thrombectomy for Acute Ischemic Stroke
|
Phase 2 | |
Completed |
NCT03484104 -
Cerebral Perfusion in Hypothermic Circulatory Arrest
|
||
Completed |
NCT03816072 -
Quantification of Dynamic and Static Cerebral Autoregulation (CA) Under Anaesthesia
|
N/A | |
Terminated |
NCT04234009 -
Lifestyle and Brain Vascular Function
|
N/A | |
Recruiting |
NCT06368635 -
The Cerebral Microcirculation Diseases and Coronary Microcirculation Disease Study
|
||
Recruiting |
NCT05394935 -
The Effects of High-intensity and Moderate-intensity Exercise on Polycystic Ovary Syndrome
|
N/A | |
Completed |
NCT01169662 -
Effects of Dietary Nitrate From Vegetable/Fruit Juice on Cerebral Blood Flow Parameters
|
Phase 4 | |
Not yet recruiting |
NCT04978558 -
NIRS vs TCD for Cerebrovascular Autoregulation During Non-cardiac Surgery
|
||
Recruiting |
NCT04391465 -
Assessment of the Relationship Between Cerebral Blood Flow and Heart Rate
|
N/A | |
Completed |
NCT03953391 -
The Effect of Tea Breaks on Cerebrovascular Perfusion During Desk Work
|
N/A | |
Recruiting |
NCT02748447 -
Automated Adjustment of Inspired Oxygen to Maintaining Regional Cerebral Oxygenation in Preterm Infants on Respiratory Support
|
N/A |