Cerebrovascular Circulation Clinical Trial
Official title:
Cerebral Vasodilator Responses in Sedentary and Exercise Trained Humans
Cerebral vasodilator responses to CO2 will be measured in young healthy adults, healthy sedentary older adults, and healthy exercise trained older adults. This variable will be examined before and after administering the cyclooxygenase inhibitor indomethacin, which has been shown to blunt cerebral vasodilator responses. In addition, the investigators will examine these counter-regulatory hemodynamic mechanisms to hypoperfusion caused by indomethacin.
Normal aging reduces cerebral blood flow and cognitive function. Aging also appears to alter
functional connectivity within the brain, which is associated with cognitive functioning.
Observational studies suggest that regular physical activity is associated with higher
cerebral blood flow and improved cognitive function. However, the mechanistic links among
regular physical activity and cerebral blood flow with advancing age are unknown. In this
context, it is unclear if aging or exercise training status alters the neurovascular coupling
of blood flow in the brain. Thus, the overall goal of this study is to examine the
age-related changes in cerebral vasodilatory capacity, an important homeostatic mechanism and
marker for effective regulation of cerebral perfusion, in order to determine how it is
mechanistically linked to cognition. Additionally, the investigators will explore the
potential beneficial effect of physical activity on the relationships between cerebral
vasodilation and cognition in humans.
The research aims are:
1. To determine if cerebral vasodilator responses are affected by age and exercise training
status in healthy adults.
2. To compare the effect of cyclooxygenase inhibition on cerebral vasodilator responses in
healthy adults.
3. To determine the neurovascular counter-regulatory response to cyclooxygenase inhibition
in healthy adults.
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