Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT00365131
Other study ID # RC96-1101
Secondary ID
Status Completed
Phase Phase 4
First received August 15, 2006
Last updated March 4, 2015
Start date December 1997
Est. completion date July 2004

Study information

Verified date March 2015
Source Sanofi
Contact n/a
Is FDA regulated No
Health authority United States: Food and Drug Administration
Study type Interventional

Clinical Trial Summary

This is a multicenter, open-label, prospective study of the efficacy of Cerezyme in treating patients with skeletal manifestations secondary to Type I Gaucher disease.

The study objective is to evaluate and quantify skeletal responses as compared to baseline in Type I gaucher disease patients receiving Cerezyme therapy for 48 months. Additional objectives were to assess the usefulness of various skeletal parameters, such as bone pain, bone crises, bone mineral density, and serum and urine bone markers, as indicative of treatment response and may be useful in dose management.


Recruitment information / eligibility

Status Completed
Enrollment 40
Est. completion date July 2004
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 10 Years to 65 Years
Eligibility Inclusion Criteria:

- Signed informed consent.

- Confirmed diagnosis of Type I Gaucher disease, with no prior enzyme replacement therapy, gene therapy or bone marrow transplantation, and who are ambulatory.

- Age 10-65 (patients 66-70 years of age are considered on a case-by-case basis following careful medical review).

- Dual energy X-ray absorptiometry (DEXA) of the femoral nech with a T-score = -1.0.

- One of more of the following signs as documented by X-ray, computed tomography (CT), or magnetic resonance imaging (MRI), or symptoms of bone disease as documented in the patient's medical history or baseline examinations: a). history of at least one bone crises; b). Erlenmeyer flask deformity of the femora in children (10-17 years old); c). osteoarticular necrosis; d). medullary infarctions; e). lytic lesions; f). pathological fractures or fractures related to Gaucher disease; g). marrow infiltration to a degree such that Rosenthal's Magnetic Resonance Score was = 3; h). bone density by quantitative computed tomography (QCT) or DEXA = 1.5 standard deviation (SD) below age-adjusted normal value; and i). fat fraction = 17%.

Exclusion Criteria:

- More than 1 joint replacement (revision surgery such as repair or replacement of a previously replaced joint is allowed).

- Pregnant, lactating or per-menopausal women.

- Active, uncontrolled infection, such as hepatitis B, hepatitis C or human immunodeficiency virus (HIV).

- Major concurrent disorders (i.e. cancer, renal disease) or disorders known to affect bone (e.g. uncontrolled thyroid disease, hyperparathyroidism, hypoparathyroidism, gastrectomy, malabsorption, inflammatory bowel disease, rheumatoid arthritis, ankylosing spondylitis).

- Medications known to affect bone homeostasis (e.g. chronic oral corticosteroids, anticonvulsants, phenytoin and phenobarbital, hyper-physiological doses of estrogen, defined as > 0.625mg, or androgens, bisphosphates, calcitonin) within the first 2 months of the first Cerezyme infusion.

- Emotional, behavioral or psychological problems, which in the judgment of the principal investigator, would interfere with the patient adequately complying with the requirement of the study.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


Intervention

Drug:
Cerezyme (imiglucerase for injection)


Locations

Country Name City State
n/a

Sponsors (1)

Lead Sponsor Collaborator
Genzyme, a Sanofi Company

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Skeletal response over 4 years of Cerezyme therapy
Primary Assess use of skeletal parameter as indicative of treatment response and use in dose management
See also
  Status Clinical Trial Phase
Active, not recruiting NCT00358150 - A Study of the Efficacy and Safety of Eliglustat Tartrate (Genz-112638) in Type 1 Gaucher Patients Phase 2
Completed NCT00364858 - Safety and Efficacy of Cerezyme® Infusions Every 4 Weeks Versus Every 2 Weeks in Type 1 Gaucher Disease Phase 4
Recruiting NCT00358943 - International Collaborative Gaucher Group (ICGG) Gaucher Disease Registry & Pregnancy Sub-registry