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Cerebral Ventriculitis clinical trials

View clinical trials related to Cerebral Ventriculitis.

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NCT ID: NCT06151392 Recruiting - Clinical trials for Ventriculitis, Infectious

Effect of Probiotic and Zinc Supplementations on the Clinical Outcome in Pediatric Patients With Ventriculitis

Start date: July 1, 2023
Phase: Phase 4
Study type: Interventional

The aim of the study is to evaluate the effect of non-antibiotic-based supplemental interventions in the management of ventriculitis among pediatric patients. The study objective is to detect the efficacy of probiotics and zinc when taken simultaneously with antibiotic treatment as immunomodulatory in increasing the recovery rate in pediatric population affected with ventriculitis.

NCT ID: NCT05904535 Recruiting - Clinical trials for Infection, Bacterial

Novel Diagnostic Methods to Identify External Ventricular Drain Associated Infections

EVD Infect II
Start date: September 21, 2022
Phase:
Study type: Observational

External ventricular drain infections are difficult to identify with current diagnostic methods. Initiation of antibiotic treatment is usually supported by indirect methods of bacterial infection, such as clinical signs or cerebrospinal fluid cell counts (CSF). As such, excessive treatment with antibiotics is common in these patients due to suspected infection while the incidence of true culture confirmed infections are less common. This study will evaluate three novel diagnostic methods for rapid direct bacterial detection in CSF, in order to assess if these can be used to guide antibiotic treatment in neurocritically ill patients, compared to CSF bacterial cultures.

NCT ID: NCT05001750 Recruiting - Clinical trials for Subarachnoid Hemorrhage

Prophylactic Antibiotics Useful With Antibiotic Impregnated External Ventricular Drains (EVDs)?

Start date: June 14, 2021
Phase: Phase 1
Study type: Interventional

The length of prophylactic antibiotic use with antibiotic impregnated External Ventricular Drains (EVD)s is unknown. This study is a randomized clinical trial with two arms: 1. twenty four hours of prophylactic antibiotic use or 2. prophylactic antibiotic use for entire duration of EVD

NCT ID: NCT04736407 Completed - Clinical trials for Ventriculitis, Cerebral

Diagnostics of External Ventricular Drain Infections in Neurosurgical Patients

EVD-Infect
Start date: October 5, 2017
Phase:
Study type: Observational
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NCT ID: NCT04426383 Completed - Clinical trials for Ventriculitis, Infectious

Evaluation of a TDM Program for Intensive Care Patients in the Cerebrospinal Fluid

EMIL
Start date: June 1, 2020
Phase:
Study type: Observational [Patient Registry]

Therapeutic drug monitoring of antibiotics in critically ill patients is a present research topic of the last ten years. Research results have shown subtherapeutic blood concentrations in those patients. However, the amount of antibiotics in the cerebrospinal fluid (CSF) in patients with ventriculitis or meningitis is still unclear. This study is a prospective study to evaluate the concentration of different antibiotics in the CSF in patients with an external ventricular drainage compared to antibiotic blood concentration.

NCT ID: NCT04178629 Recruiting - Pharmacokinetics Clinical Trials

Ceftobiprole's Cerebrospinal Fluid Penetration in Patients With External Ventricular Derivation (CEFTO-EVD)

CEFTO-EVD
Start date: July 2, 2019
Phase:
Study type: Observational

The Cerebrospinal fluid penetration of ceftobiprole has been studied in an animal model of meningitidis. Ceftobiprole is bactericidal, well tolerated and it has anti-biofilm activity. Altogether, these pharmacodynamics and pharmacokinetic properties of ceftobiprole are suitable for its use in case of External Ventricular Derivation(EVD)-related ventriculitis. Nowadays there are no human studies on the penetration and efficacy of ceftobiprole in the CSF. The study aims to evaluate characteristics of the CSF penetration of Ceftobiprole after intravenous administration in patients with EVD, that need for a concomitant infection this therapy (prescribed by an Infectious Diseases doctor).