Cerebral Small Vessels Disease Clinical Trial
Official title:
Measure of Specific Determinants of the Cerebral Small Vessel Disease in HIV+ Patients
Cerebral small vessel disease (CSVD) is a major cause of cognitive impairment and disability
in the general population, secondary to the accumulation of asymptomatic elementary lesions.
CSVD is directly correlated with age and cardiovascular risk factors and therefore would be
challenging in term of public health care in the future. While HIV patients share the same
cardiovascular risk factors and they are often diagnosed with cognitive impairment and
frailty, CSVD has not been yet described in this population.
The global aim is to study and describe the CSVD in the HIV+ population by: (1) correlating
the CSVD and the macro-vascular disease of the head and brain; (2) correlating the CSVD with
the ocular (structural sentinel organ) and kidney (functional sentinel organ) micro-vascular
disease.
HIV+/CSVD+ patients will have a complementary work-up with conventional MRI/MRA, thorough
vascular explorations, and neurologic examination to evaluate the severity of the CSVD, the
macro-vascular disease and the cerebral atrophy. They will have a full ophthalmic examination
and specific kidney explorations to evaluate the micro-vascular disease of this two sentinel
organs. The same number of HIV+/CSVD- matched patients will have the same work-up.
We are expecting to show the relationship between CSVD and cardiovascular risk factors in
order to propose specific prevention. We will correlate the CSVD with the neurologic and
cognitive function as it is already proved in the general population. We will correlate the
CSVD with the ocular and kidney micro-vascular disease to propose fast, easy and cheap
screening tools for the CSVD in the HIV+ population.
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