The Effects of Mood on Cerebral Perfusion

Cerebral Perfusion Clinical Trial

Official title:

The Effects of Mood on Cerebral Perfusion

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03302130
• Other study ID #: EC/2015/0528
• Status: Completed
• Phase: N/A
• Start date: January 8, 2016
• Est. completion date: November 17, 2017

Study information

• Verified date: November 2022
• Source: University Ghent
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Measuring brain perfusion is biased by a inter- and intrasubject variability, caused by physiological and lifestyle factors. In this study, the investigators want to investigate the effects of a different mood state (neutral, positive and negative mood), induced using subjects own memories, on both global and regional cerebral perfusion, measured with arterial spin labeling.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 48
• Est. completion date: November 17, 2017
• Est. primary completion date: October 30, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• Healthy university students

• between 18 and 30 years old

Exclusion Criteria:

• No informed consent

• Not using hormonal contraception

• MRI-contraindications

• Claustrophobia

• Pregnancy

• Chronic diseases and chronic medication use

Related Conditions & MeSH terms

• Cerebral Perfusion

Intervention

Behavioral:
• Mood induction (using own memories)
Subjects deliver three positive, three negative and three neutral memories 30 seconds reliving a memory - answering questions about the memory - reliving memory for 2 minutes during ASL-MRI

Device:
• Arterial spin labeling MRI
Single PLD PCASL
• Physiological monitoring
During MRI: heart rate, end-tidal CO2, respiratory rate and skin conductance

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University Ghent

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Regional Cerebral perfusion (ml/100g/min) during positive mood induction	Effect of positive mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.	2 minutes (ASL scan during mood state induction)
Primary	Regional Cerebral perfusion (ml/100g/min) during negative mood induction	Effect of negative mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.	2 minutes (ASL scan during mood state induction)
Primary	Regional Cerebral perfusion (ml/100g/min) during neutral mood induction	Effect of neutral mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.	2 minutes (ASL scan during mood state induction)
Primary	Regional Cerebral perfusion (ml/100g/min) after positive mood induction	Effect of positive mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.	2 minutes (ASL scan after mood state induction)
Primary	Regional Cerebral perfusion (ml/100g/min) after negative mood induction	Effect of negative mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.	2 minutes (ASL scan after mood state induction)
Primary	Regional Cerebral perfusion (ml/100g/min) after neutral mood induction	Effect of neutral mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.	2 minutes (ASL scan after mood state induction)