Desflurane Versus Propofol in the Sitting Position

Cerebral Ischemia Clinical Trial

Official title:

International Review Board of Gachon University Gil Hospital

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01436799
• Other study ID #: GIRBA2466
• Status: Completed
• Phase: N/A
• First received: September 15, 2011
• Last updated: August 25, 2013
• Start date: March 2011
• Est. completion date: August 2011

Study information

• Verified date: August 2013
• Source: Gachon University Gil Medical Center
• Contact: n/a
• Is FDA regulated: No
• Health authority: Korea: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

The investigators hypothesized that both propofol and desflurane would decrease the regional oxygen saturation (rSO2) but propofol is likely to reduce rSO2 more than sevoflurane when patients are raised to the sitting position.

Description:

The investigators hypothesized that both propofol and desflurane would decrease the rSO2 but propofol is likely to reduce rSO2 more than sevoflurane when patients are raised to the sitting position. Therefore, the purpose of this study was to investigate the effect of desflurane and propofol on rSO2 values during the beach chair position for shoulder arthroscopy.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: August 2011
• Est. primary completion date: August 2011
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 20 Years to 65 Years

Eligibility

Inclusion Criteria:

• Forty patients,

• ASA class I or II,

• undergoing shoulder arthroscopy

Exclusion Criteria:

• Patients with history of cerebrovascular disease, coronary occlusive disease and/or obesity (body mass index > 30) were excluded from this study.

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Cerebral Infarction
• Cerebral Ischemia

Intervention

Drug:
• propofol
anaesthesia was induced with the effect-site concentration of propofol 5.0 µg ml-1 mainly.
• Desflurane
anaesthesia was maintained by desflurane 4-7vol%
• alfentanil
administration of alfentanil 10 µg kg-1 for anesthetic induction
• Rocuronium
administration of rocuronium 0.6 mg kg-1 for anesthetic induction

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Gachon University Gil Medical Center

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Regional Cerebral Oxygen Satuation (rSO2)	definitive values of regional cerebral oxygen saturation(rSO2,%) values are described as mean (SD)	1, 3, 5, 7, and 9 min after the beach chair position	Yes