Impact of Neutrophil Extracellular Traps (NET) on Thrombolysis in Acute Phase of Cerebral Ischemia

Cerebral Infarct Clinical Trial

— THINK  

Official title:

Impact of Neutrophil Extracellular Traps (NET) on Thrombolysis in Acute Phase of Cerebral Ischemia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02948465
• Other study ID #: 2016/37
• Status: Completed
• Start date: July 22, 2016
• Est. completion date: December 10, 2016

Study information

• Verified date: August 2019
• Source: Hopital Foch
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Cerebral infarcts represent a major cause of morbidity/mortality in spite of therapeutics for a premature recanalisation (intravenous recombinant tissue plasminogen activator (rt-PA) and thrombectomy). Thrombolysis failure by the administration of rt-PA is frequent, in particular in proximal occlusion. Experimental studies suggest that neutrophils could play an important role in the thrombus development via the organization of a network (NET) within the thrombus. Targeting this network of NET could, in addition to the fibrinolysis, increase the rate of recanalisation and thus improve the neurological prognostic after a cerebral infarct.

The aim of the research is to Study of the biochemical and histological composition of the stemming thrombi of cerebral thrombectomies with in vitro analysis of the sensibility in the thrombolysis induced by rt-PA +/- Desoxyribonuclease I (DNase I).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 125
• Est. completion date: December 10, 2016
• Est. primary completion date: December 10, 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patient over 18

• Having a cerebral infarct consecutive to a wide calibre arterial occlusion

• taken care for mechanical thrombectomy

Exclusion Criteria:

• Patient benefiting from a legal protective measure

• Pregnant or breast-feeding woman

• Opposition of the patient to participate in the study

Related Conditions & MeSH terms

• Brain Ischemia
• Cerebral Infarct
• Cerebral Infarction
• Ischemia

Locations

Country	Name	City	State
France	Hopital Foch	Suresnes

Sponsors (1)

Lead Sponsor	Collaborator
Hopital Foch

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Correlation coefficient between biochemical and histological composition of the thrombus and the sensibility in the in vitro fibrinolysis and the origin of the thrombus.		1 day