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Clinical Trial Summary

Oral supplements containing exogenous ketones have recently become available and represent a novel tool for increasing plasma ketone bodies without the need for dietary restriction. Early evidence suggests that oral ketone supplements may enhance cerebral blood flow (CBF). However, a higher dose of a ketone monoester has been shown to slightly lower blood pH and reduce end-tidal CO2 (PetCO2) due to compensatory hyperventilation, which is accompanied by parallel reductions in CBF. Whether reductions in PetCO2 causes reductions in CBF is currently unknown. The purpose of this study is to investigate the effect of manipulating PetCO2 at normocapnia (PetCO2 maintained at baseline) or poikilocapnia (no PetCO2 targeting; breathing room air), following the ingestion of a dose of a ketone monoester on CBF and cerebrovascular reactivity to CO2 in young adults.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06217159
Study type Interventional
Source McMaster University
Contact Jeremy J Walsh, PhD
Phone 9055259140
Email walshj18@mcmaster.ca
Status Recruiting
Phase N/A
Start date January 19, 2024
Completion date August 31, 2024

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