COPD Clinical Trial
Official title:
Acute Non-invasive Ventilation Reduces Cerebral Blood Flow in COPD Patients and Healthy Controls Without Effects on Cognitive Function
Objectives: Investigate the acute NIV effects on CBF and cognitive functions in COPD patients. Methods: Nine non-hypercapnic stable COPD subjects (FEV1/FVC < lower limit of normal) and twelve healthy controls were enrolled. CBF (transcranial Doppler), cognitive functions, respiratory and cardiovascular response were tested at baseline, during and after non-invasive ventilation.
Nine COPD patients were screened from the Respiration Laboratory (RespLab) of Federal
University of Ceará, and twelve sedentary controls from the general population were also
assessed. All patients were under stable medical treatment at least two months, and COPD
diagnosis was made according to GOLD guidelines. Patients were excluded if they had heart
disease, arterial hypertension, other debilitating pulmonary or non-pulmonary diseases,
depression, preexisting psychiatric or neurologic disorders, stroke, motor impairment,
visual or hearing disabilities, mini-mental scale examination score below 20 points, and any
disease that could influence the effectiveness of NIV application or the performance of
cognitive tests. The control group consisted of healthy and nonsmoking volunteers.
After study enrollment, 15 days before the performance of the experimental protocol,
patients performed neurocognitive tests (Digit Span Test, Digit Symbol-Coding, Corsi
Block-tapping, Trail Making Test A and B and Stroop Test) and NIV adaptation. Pulmonary
function (spirometry) was measured in all subjects after a thorough medical history and
physical examination. Before initiating the protocol, patients were asked about discomfort
related to NIV or any aspect of the experiment. CBF, capnometry, arterial blood gases (ABG)
and neurocognitive tests were performed before, during and after NIV.
CBF was measured by transcranial Doppler by mean of LMCAFV immediately before NIV, during
NIV at 5, 30 and 60 minutes and after NIV removal at 5 and 30 minutes. ABG were collected
immediately before the experiment, after one hour of NIV breathing and 30 minutes after NIV
discontinuation. Respiratory rate (RR), tidal volume (VT), oxygen saturation by pulse
oximetry (SpO2), heart rate (HR), minute ventilation (VE) and mean systemic arterial blood
pressure (MAP) were continuously measured by a multiparameter monitor (Dixtal DX-2010™,
Dixtal, Manaus, Brazil) both on spontaneous respiration and NIV.
Subjects were tested in the morning and investigated while awake and at the supine position,
throughout the experiment.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT06000696 -
Healthy at Home Pilot
|
||
Active, not recruiting |
NCT03927820 -
A Pharmacist-Led Intervention to Increase Inhaler Access and Reduce Hospital Readmissions (PILLAR)
|
N/A | |
Completed |
NCT04043728 -
Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start Study
|
N/A | |
Completed |
NCT04105075 -
COPD in Obese Patients
|
||
Recruiting |
NCT05825261 -
Exploring Novel Biomarkers for Emphysema Detection
|
||
Active, not recruiting |
NCT04075331 -
Mepolizumab for COPD Hospital Eosinophilic Admissions Pragmatic Trial
|
Phase 2/Phase 3 | |
Terminated |
NCT03640260 -
Respiratory Regulation With Biofeedback in COPD
|
N/A | |
Recruiting |
NCT04872309 -
MUlti-nuclear MR Imaging Investigation of Respiratory Disease-associated CHanges in Lung Physiology
|
||
Recruiting |
NCT05145894 -
Differentiation of Asthma/COPD Exacerbation and Stable State Using Automated Lung Sound Analysis With LungPass Device
|
||
Withdrawn |
NCT04210050 -
Sleep Ventilation for Patients With Advanced Hypercapnic COPD
|
N/A | |
Terminated |
NCT03284203 -
Feasibility of At-Home Handheld Spirometry
|
N/A | |
Recruiting |
NCT06110403 -
Impact of Long-acting Bronchodilator- -Corticoid Inhaled Therapy on Ventilation, Lung Function and Breathlessness
|
Phase 1/Phase 2 | |
Active, not recruiting |
NCT06040424 -
Comparison of Ipratropium / Levosalbutamol Fixed Dose Combination and Ipratropium and Levosalbutamol Free Dose Combination in pMDI Form in Stable Chronic Obstructive Pulmonary Disease (COPD) Patients
|
Phase 3 | |
Recruiting |
NCT05865184 -
Evaluation of Home-based Sensor System to Detect Health Decompensation in Elderly Patients With History of CHF or COPD
|
||
Recruiting |
NCT04868357 -
Hypnosis for the Management of Anxiety and Breathlessness During a Pulmonary Rehabilitation Program
|
N/A | |
Completed |
NCT01892566 -
Using Mobile Health to Respond Early to Acute Exacerbations of COPD in HIV
|
N/A | |
Completed |
NCT04119856 -
Outgoing Lung Team - a Cross-sectorial Intervention in Patients With COPD
|
N/A | |
Completed |
NCT04485741 -
Strados System at Center of Excellence
|
||
Completed |
NCT03626519 -
Effects of Menthol on Dyspnoea in COPD Patients
|
N/A | |
Recruiting |
NCT04860375 -
Multidisciplinary Management of Severe COPD
|
N/A |