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Cerebral Aneurysm clinical trials

View clinical trials related to Cerebral Aneurysm.

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NCT ID: NCT02281721 Terminated - Cerebral Aneurysm Clinical Trials

Surpass Flow Diverter for Intracranial Aneurysms: SURMOUNT Registry Data Collection

Start date: March 18, 2015
Phase:
Study type: Observational [Patient Registry]

The purpose of this observational post-marketing registry will be to collect and analyze safety, effectiveness, and quality of life outcomes, during and after treatment with the Surpass Flow Diverter. Health Economics assessments (cost data) will also be collected and analyzed.

NCT ID: NCT02162654 Recruiting - Cerebral Aneurysm Clinical Trials

Remote Ischemic Preconditioning for Intracranial Aneurysm Treatment

RIPAT
Start date: November 2013
Phase: N/A
Study type: Interventional

The RIPAT study is a prospective, randomized, double-blind study organized by the neurovascular group of the Clinical Department of Neurosurgery of Innsbruck Medical University, Innsbruck, Austria. Patients aged 18+ in whom the treatment of an un-ruptured intracranial aneurysm is indicated are eligible for study participation. Prior to aneurysm treatment, with the patient already under general anesthesia, the blood supply to an arm will be restricted for 3x 5minutes by inflating a standard blood pressure cuff. The study hypothesis is that this "remote ischemic preconditioning" maneuver is able to prevent a stroke during the following treatment of the aneurysm.

NCT ID: NCT02011321 Withdrawn - Clinical trials for Subarachnoid Hemorrhage

Clevidipine for Vasospasm After Subarachnoid Hemorrhage (SAH)

CLEVAS
Start date: March 2014
Phase: Phase 2
Study type: Interventional

Vasospasm occurs frequently after aneurysmal subarachnoid hemorrhage and can lead to strokes. The investigators will investigate if infusion of a novel drug, clevidipine, will decrease vasospasm during the infusion and post infusion period using transcranial doppler monitoring of patients with subarachnoid hemorrhage and moderate severity vasospasm

NCT ID: NCT01943591 Completed - Cerebral Aneurysm Clinical Trials

DELTA Trial: Does Embolization With Larger Coils Lead to Better Treatment of Aneurysms Trial

DELTA
Start date: November 13, 2013
Phase: N/A
Study type: Interventional

Endovascular treatment with platinum coils is safe and effective in preventing rebleeding of intracranial aneurysms. Unfortunately, endovascular treatment of aneurysms with coils has been associated with incomplete occlusion at initial treatment (remnant) or at follow-up (recurrence). This in some studies has been as high as 20%. While many such aneurysm remnants or recurrences exhibit benign behavior, many require retreatment to prevent future hemorrhage. A recent randomized controlled trial of aneurysm coiling revealed that aneurysms between 2 and 9.9 mm diameter were more likely to have an improved angiographic and composite clinical outcome when treated with hydrogel-coated coils, an improvement inferred to result from higher packing density afforded by hydrogel expansion(1). The use of hydrogel coils is associated with technical difficulties related to expansion and limited time for deployment. The investigators theorize that similar results could be achieved by using more voluminous bare platinum coils, leading to improved packing density compared to smaller caliber coils, and thus result in lower incidence of remnants or residuals. The relationship between packing densities and composite clinical endpoints having never been shown in a robust fashion, the investigators therefore propose a randomized clinical trial opposing coiling with soft 15-caliber coils to 10-caliber bare platinum coils in aneurysms varying in size from 3 to 9.9 mm. To test the hypothesis that 15-caliber coiling systems are superior to standard 10-caliber coils in achieving better composite outcomes, the investigators propose the DELTA trial: Does Embolization with Larger coils lead to better Treatment of Aneurysms trial, a randomized controlled blinded trial with 2 subgroups of 282 patients each, 564 total: Subgroup 1: Coiled with a maximum proportion of 15-caliber coils as conditions allow Subgroup 2: Coiled with 10-caliber coils.

NCT ID: NCT01919775 Completed - Clinical trials for Subarachnoid Hemorrhage

Amnesia After Surgery for Anterior Communicating Aneurysm: High Resolution Magnetic Resonance (MR) Imaging Findings

Start date: December 2007
Phase: N/A
Study type: Observational [Patient Registry]

To clarify whether amnesia after treatment of anterior communicating aneurysm (ACoA)is related to infarcts caused by occlusion or damage of the perforating artery of the ACoA, we used 3.0-T 3D high resolution MR imaging to identify and localize infarcts in patients with amnesia following treatment of ACoA aneurysm.

NCT ID: NCT01895881 Withdrawn - Menopause Clinical Trials

Estrogen Therapy as Prevention in the Progression of Aneurysm (EPPA) Trial

EPPA
Start date: April 2013
Phase: Phase 2
Study type: Interventional

This study aims to determine if hormone replacement therapy, given during perimenopause may prevent the progression of saccular cerebral aneurysms.

NCT ID: NCT01878136 Withdrawn - Clinical trials for Subarachnoid Hemorrhage

Effect of Intraventricular tPA Following Aneurysmal Subarachnoid Hemorrhage

Start date: March 2015
Phase: Phase 1/Phase 2
Study type: Interventional

This study will evaluate the hypothesis that the administration of intraventricular tPA reduces the rates of cerebral vasospasm and ventriculoperitoneal shunt-dependent hydrocephalus in patients with aneurysmal subarachnoid hemorrhage.

NCT ID: NCT01690364 Completed - Brain Tumor Clinical Trials

Comparison of the Effects of Vecuronium and Cisatracurium on Electrophysiologic Monitoring During Neurosurgery

Start date: July 2012
Phase: N/A
Study type: Interventional

Recently intraoperative motor evoked potential monitoring (MEP) is widely used to reduce neural damage during neurosurgery. As neuromuscular blockade(NMB) during MEP monitoring decreases the amplitude of MEP, partial NMB is usually maintained during general anesthesia. Continuous infusion of NMB agent is preferred than bolus infusion during MEP monitoring. There are a lot of NMB agents in clinical use. But there have been no reports about the effect of changing NMB agent on efficacy of MEP monitoring. Therefore, the investigators performed a randomized controlled trial to evaluate the effect of changing NMB agent on the variability of MEP amplitude during neurosurgery.

NCT ID: NCT01655784 Active, not recruiting - Cerebral Aneurysm Clinical Trials

Framing Eighteen Coils in Cerebral Aneurysms Trial

FEAT
Start date: December 4, 2012
Phase: N/A
Study type: Interventional

This trial is being conducted in order to compare angiographic outcomes in patients receiving 0.014-0.0155" platinum framing and filling coils (larger diameter coils) versus those treated solely with coils less than 0.014" (with a standard diameter). Hypothesis: Angiographic occlusion at follow-up imaging will be more frequent in patients receiving 0.014-0.0155" platinum coils during embolization compared to those receiving smaller-diameter coils.

NCT ID: NCT01460563 Recruiting - Cerebral Aneurysm Clinical Trials

Valproic Acid, Magnesium Sulphate, Rocuronium Requirement, Postoperative Analgesia

Start date: October 2011
Phase: N/A
Study type: Interventional

The investigators hypothesized that valproic acid will increase rocuronium requirement and MgSO4 infusion would reduce requirement of muscle relaxant in craniotomy patients preloaded with sodium valproate.