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SEarchiNg biomarkErs Cerebral Amyloid Angiopathy (SENECA) — SENECA  

Cerebral Amyloid Angiopathy Clinical Trial

Official title:
SEarchiNg biomarkErs Cerebral Amyloid Angiopathy (SENECA): Italian Network for the Study of CAA

Clinical Trial Summary

Cerebral amyloid angiopathy (CAA) is one of the major types of cerebral small vessel disease, and a leading cause of spontaneous intracerebral hemorrhage and cognitive decline in elderly patients. Although increasingly detected, a number of aspects including the pathophysiology, the clinical and neuroradiological phenotype and the disease course are still under investigation. The incomplete knowledge of the disease limits the implementation of evidence based guidelines on patient's clinical management and the development of treatments able to prevent or reduce disease progression.

The SENECA (SEarchiNg biomarkErs of Cerebral Angiopathy) project is the first Italian multicentre cohort study aimed at better defining the disease natural history and identifying clinical and neuroradiological markers of disease progression. By a multidisciplinary approach and the collection of a large and well phenotyped series and biorepository of CAA patients, the study is ultimately expected to improve the diagnosis and the knowledge of CAA pathophysiological mechanisms.

Clinical Trial Description

The SENECA is an Italian multicenter network integrating the experience of neurologists, neuroradiologists, neuro-ophthalmologists and biologists and allowing the standardized collection of a well-characterized wide series of sporadic and familial CAA patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04204642
Study type Observational
Source Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Contact Anna Bersano, MD, Phd
Phone +39022394
Email anna.bersano@istituto-besta.it
Status Recruiting
Phase
Start date June 1, 2020
Completion date December 31, 2024
View Details
See also
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