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Cerebellar Ataxia clinical trials

View clinical trials related to Cerebellar Ataxia.

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NCT ID: NCT06152133 Active, not recruiting - Cerebellar Ataxia Clinical Trials

Telerehabilitation, Core Stability Exercises and Hereditary Ataxia (TRCore-ataxia)

TRCore-ataxia
Start date: March 1, 2024
Phase: N/A
Study type: Interventional

Hereditary ataxias (HA) are a heterogeneous group of degenerative diseases of the cerebellum, brain stem and spinal cord. People who suffer from AH, among other symptoms, present deficiencies in the stability of the trunk, which leads to an alteration in postural control, with a strongly influential factor in the loss of balance and gait disorders. Improving the functionality of these physical aspects can help reduce the rate of falls, increase autonomy and quality of life for people with HA. Evidence suggests that rehabilitation strategies based on core stability exercises (CSE) are effective in improving balance and postural control in several neurological diseases, such as stroke. However, there is little evidence with people with HA. In a previous study carried out by researchers of this project, in which an EEC exercise program was piloted at home, low adherence to treatment was perceived due to the little follow-up that was given to the participants. Therefore, including telerehabilitation in these programs would increase follow-up and could influence adherence.

NCT ID: NCT05884086 Active, not recruiting - Ataxia, Gait Clinical Trials

Ataxia GAA-FGF14 - Descriptive Genetic and Clinical Study

GAA-FGF14
Start date: May 1, 2023
Phase:
Study type: Observational

Cerebellar ataxias of late onset are of undetermined etiology in many cases. A new cause of late-onset cerebellar ataxia was discovered in January 2023 corresponding to an expansion of GAA triplets in intron 1 of the FGF14 gene. However, this cerebellar ataxia is still poorly known and requires further investigations to know its clinical phenotype and its evolution in order to propose a diagnosis and a genetic counseling adapted to patients and families. The objective of our study will be to describe the clinical and genotypic phenotype of patients with GAA-FGF14

NCT ID: NCT05826171 Active, not recruiting - Clinical trials for Spinocerebellar Ataxia Type 3

Priming Motor Learning Through Exercise in People With Spinocerebellar Ataxia

PRIME-Ataxia
Start date: February 6, 2023
Phase: N/A
Study type: Interventional

PRIME-Ataxia is a randomized controlled trial that aims to determine the feasibility and efficacy of an 8-week telehealth intervention of high intensity aerobic exercise prior to balance training compared to an 8-week telehealth intervention of low intensity exercise prior to balance training in people with spinocerebellar ataxias (SCAs). The investigators additionally aim to explore changes in motor skill learning on a novel motor skill task in a sub-group of participants pre and post intervention.

NCT ID: NCT05485987 Active, not recruiting - Friedreich Ataxia Clinical Trials

A Study of Vatiquinone for the Treatment of Participants With Friedreich Ataxia

Start date: October 13, 2022
Phase: Phase 2
Study type: Interventional

The primary objective of the study is to assess the pharmacokinetics (PK) and safety of vatiquinone administered in participants with Friedreich ataxia (FA) younger than 7 years.

NCT ID: NCT05351255 Active, not recruiting - Cerebellar Ataxia Clinical Trials

Motor Learning After Cerebellar Damage: The Role of the Primary Motor Cortex

Start date: July 1, 2022
Phase: N/A
Study type: Interventional

This study will determine (1) whether baseline inhibitory activity in the primary motor cortex can predict motor learning ability in individuals with cerebellar degeneration, and (2) whether modulating primary motor cortex activity with non-invasive brain stimulation alters motor learning ability in this population.

NCT ID: NCT05168774 Active, not recruiting - Friedreich Ataxia Clinical Trials

FRDA Investigator Initiated Study (IIS) With Elamipretide

ELViS-FA
Start date: March 3, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

To evaluate the safety, tolerability, and activity of Elamipretide in treating vision loss in Friedreich Ataxia (FRDA).

NCT ID: NCT05157802 Active, not recruiting - Cerebellar Ataxia Clinical Trials

Promoting Physical Activity Engagement for People With Early-stage Cerebellar Ataxia

EngageAtaxia
Start date: March 26, 2021
Phase: Phase 1
Study type: Interventional

Engage-Ataxia will implement a physical activity coaching program for people with cerebellar ataxia at Teachers College, Columbia University. This program expands upon the current Engage program for people with Parkinson's disease (Engage-PD), an exercise coaching program for people with early stage Parkinson's disease to target individuals with early stage cerebellar ataxia. Engage-Ataxia will utilize a physical or occupational therapist to provide up to five one-on-one coaching sessions for individuals newly diagnosed with cerebellar ataxia. Therapists will work with participants to provide individualized structured support to facilitate and optimize exercise uptake as one part of comprehensive disease management. Participants will undertake two assessments three months apart, and will receive coaching interventions via Zoom healthcare platform. The primary objective of this program is to increase physical activity and exercise engagement in individuals with early stage cerebellar ataxia. This feasibility study will provide preliminary data and insight into the benefits of a remote coaching intervention for people with cerebellar ataxia.

NCT ID: NCT05024240 Active, not recruiting - Cerebellar Ataxia Clinical Trials

Interaction of the Cognitive and Sensory-cognitive Tasks With Postural Stability in Individuals With Stability Disorders

Start date: October 10, 2018
Phase: N/A
Study type: Interventional

The aim of this study is to describe the interaction of the cognitive and visual-cognitive task with postural stability in patients suffering by cerebellar ataxia. Investigators will measure changes in postural stability parameters and in secondary task performance, which should show the ability of the patients to manage the dualtask situations.

NCT ID: NCT05002218 Active, not recruiting - Cerebellar Ataxia Clinical Trials

Training in Ataxia - Individuals With Degenerative Cerebellar Diseases

Start date: January 31, 2022
Phase: N/A
Study type: Interventional

Balance and aerobic training show promise as treatments for degenerative cerebellar diseases, but the neural effects of both training methods are unknown. The goal of this project is to evaluate how each training method impacts the brain, and particularly, the degenerating cerebellum. Various neuroimaging techniques will be used to accomplish this goal and test the hypothesis that balance training impacts brain structures outside the cerebellum whereas aerobic training causes more neuroplastic changes within the cerebellum.

NCT ID: NCT04991701 Active, not recruiting - Clinical trials for Ataxia Telangiectasia

A National Retrospective Population Based Cohort Study of the Natural History of Ataxia Telangiectasia

N-HAT
Start date: September 14, 2018
Phase:
Study type: Observational

This is a retrospective observational study of natural-history of ataxia-telangiectasia. Understanding the natural history and its variability is not only vital to planning effective patient-centred services, and counselling patients and their families, but will also inform the design of future clinical research, particularly clinical trials.