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A Phase II Trail of Chidamide ,Rituximab and Methotrexate in Lymphoma Patients — C-R-HDMTX  

Central Nervous System Lymphoma Clinical Trial

Official title:
A Phase II， Single-arm Trail of Chidamide Combined With Rituximab and High-dose Methotrexate in Previously Untreated Patients With Primary Central Nervous System Lymphoma

Clinical Trial Summary

This study will evaluate the efficacy, safety and patient reported outcomes of chidamide 20 mg biw PO day1-14 and rituximab 375 mg/m2 IV given on day 1 and methotrexate 3.5g/m2 IV given on day 2 of every 21-day cycle for 6 cycles in untreated patients with primary central nervous system lymphoma.

The primary study endpoint will be complete response (CR) rate as assessed by the investigator. The hypothesis is previously untreated patients with primary central nervous system lymphoma could achieve a CR rate of 80% with C-R-HDMTX.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04516655
Study type Interventional
Source Fudan University
Contact Fangfang Lv
Phone +86-18018312613
Email lvff80@163.com
Status Not yet recruiting
Phase Phase 2
Start date September 1, 2020
Completion date August 30, 2023
View Details
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