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Nordic Study in Newly Diagnosed Primary Central Nervous System (CNS) Lymphoma

Central Nervous System Lymphoma Clinical Trial

Official title:
Immunochemotherapy in Primary Central Nervous System Lymphoma With Rituximab, HD-MTX, HD-Ara C, Cyclophosphamide, Ifosfamide, Vincristine, Vindesine, Temozolomide and DepoCyte Induction Followed by Maintenance Treatment in Elderly Patients With Temozolomide.

Clinical Trial Summary

The purpose of the study is to test the efficacy and tolerability of a multiagent chemotherapy treatment regimen without radiotherapy in patients with newly diagnosed lymphoma in the brain.

Clinical Trial Description

The objective of the study is 1. To investigate the efficacy and safety of a high-dose methotrexate-based induction polychemotherapy regimen combined with Rituximab and intraspinal DepoCyte followed by temozolomide maintenance treatment in newly diagnosed primary central nervous system lymphoma 2. To assess the long term outcome concerning neurotoxicity ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01458730
Study type Interventional
Source University of Aarhus
Contact
Status Completed
Phase Phase 2
Start date May 2007
Completion date August 2022
View Details
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