Clinical Trials Logo

Clinical Trial Summary

Project rationale: Since 2017, multiple sclerosis diagnosis should match the new McDonald criteria in which a "no better explanation than MS" should be fulfilled. However, many patients present with red flags that lead to a complex diagnostic work-up. There are no available biomarkers that permit to confirm or roll out MS diagnosis in such cases. Therefore, we lack biological markers that can help in the diagnosis of patients presenting with suspected MS. Many studies have found that serum and cerebrospinal fluid (CSF) cytokines could help to differentiate MS from other diseases such as neuromyelitis optica spectrum disorders (i.e., IL-6) or neurosarcoidosis (i.e., sIL-2R). Serum and CSF kappa free light chains have also shown good diagnosis performance in MS. In daily practice, our MS tertiary center already perform the analysis of CSF concentrations of IL-1β, sIL-2R, IL-6, IL-10, and serum and CSF kappa and lambda free light chains to roll out other central nervous system (CNS) autoimmune diseases in patients presenting with white matter hyperintensities (WMH). Objective: To correlate CSF IL-1β, sIL-2R, IL-6, IL-10, serum and CSF kappa and lambda free light chains with the final diagnosis in patients presenting to our MS tertiary center with suspected MS to identify a specific inflammatory biomarker profil involved in MS and other CNS autoimmune diseases. The methodology: This is an observational study. All patients ongoing a routine diagnostic work-up for suspected MS from june 2020 to june 2022 in our MS tertiary center will be analyzed. Cerebrospinal fluid IL-1β, sIL-2R, IL-6, IL-10, serum and CSF kappa and lambda free light chains will be correlated with the final diagnosis to ultimately find MS associated biomarkers.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05056740
Study type Observational
Source Centre Hospitalier Universitaire de Nice
Contact
Status Recruiting
Phase
Start date June 1, 2020
Completion date June 1, 2022

See also
  Status Clinical Trial Phase
Completed NCT00116337 - Spinal Cord Stimulation to Restore Cough N/A
Enrolling by invitation NCT05080777 - Pilot Pragmatic Clinical Trial to Embed Tele-Savvy Into Health Care Systems N/A
Recruiting NCT04871464 - Role and Mechanism of Probiotics in Improving Motor Symptoms in Mild to Moderate Parkinson's Disease Phase 4
Not yet recruiting NCT04908241 - Telerehabilitation With Aims to Improve Lower Extremity Recovery Post-Stroke (TRAIL-RCT) N/A
Completed NCT01915368 - Determining Optimal Post-Stroke Exercise (DOSE) N/A
Completed NCT01211873 - Safety and Efficacy Evaluation of DOTAREM® in MRI of Central Nervous System (CNS) Lesions Phase 3
Completed NCT00395460 - Efficacy and Safety Study to Evaluate Gadavist (Gadobutrol) as Contrast Agent in Magnetic Resonance Imaging (MRI) of Brain or Spine Diseases in Chinese Patients Phase 3
Recruiting NCT03270189 - Effect of the Visual Information Change in Functional Dystonia N/A
Recruiting NCT03911388 - HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors Phase 1
Active, not recruiting NCT04912115 - Randomized, Double-Blind, Active Placebo-Controlled Study of Ketamine to Treat Levodopa-Induced Dyskinesia Phase 2
Recruiting NCT03994822 - pRESET for Occlusive Stroke Treatment N/A
Completed NCT04283253 - Predictors of Response in Chronic Stroke N/A
Not yet recruiting NCT05019105 - Phase 1 ALKS 1140 in Healthy Adults Phase 1
Recruiting NCT02684825 - Detection of Silent Atrial Fibrillation aFter Ischemic StrOke Phase 4
Completed NCT02368223 - Feasibility of the Portable YouGrabber System N/A
Completed NCT01445639 - Dexmedetomidine in Patients After Intracranial Surgery Phase 4
Completed NCT00995215 - Sub-study to Spinal Cord Stimulation to Restore Cough N/A
Completed NCT00766363 - Safety, Tolerability, and Pharmacokinetic Study of EVP-6124 in Patients With Alzheimer's Disease Phase 1
Completed NCT00780078 - Clinical Evaluation of Swallowing Disorders as a Predictor of Extubation Failure N/A
Recruiting NCT03678194 - Treating Depression on a Day-to-day Basis: Development of a Tool for Physicians Based on a Smartphone Application N/A