Central Hypothyroidism, a Novel Laboratory Measurement

Central Hypothyroidism Clinical Trial

Official title: Central Hypothyroidism,a New Laboratory Approach for Hormone Measurement

Status Enrolling by invitation

Clinical Trial Summary

Medical management of central hypothyroidism is controversial due to lack of reference for evaluation of pituitary negative feedback. Therefore, titration of medical treatment is based on T4 levels, measured with variable laboratory methods. Patients who have central hypothyroidism usually have concomitant deficiencies in other pituitary hormones for which they need replacement therapy such as steroids, testosterone and growth hormone. This combined hormone deficiency makes clinical and laboratory evaluation challenging among these patients. Symptomatically, central hypothyroidism is relatively mild and lack non-specific and it might be overlooked due to other hormonal deficiencies. Replacement therapy for central hypothyroidism is titrated by arbitrary target free T4 levels of above 50th percentile of normal. The goal of our study is to compare the standard results from well known measure methods to a new method for measuring Ft4 using Liquid chromatography - tandem mass spectrometry.

Clinical Trial Description

n/a

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Related Conditions & MeSH terms

• Central Hypothyroidism
• Hypothyroidism

• NCT number: NCT01280292
• Study type: Interventional
• Source: Sheba Medical Center
• Status: Enrolling by invitation
• Phase: N/A
• Start date: February 2011
• Completion date: July 2013