Cellulitis Clinical Trial
Official title:
A Double Blind Randomised Control Trial to Measure the Effect of the Addition of Clindamycin to Flucloxacillin for the Treatment of Limb Cellulitis
The aim of this study is to see whether the addition of Clindamycin, a protein inhibiting antibiotic, to the standard antibiotic treatment of limb cellulitis, with Flucloxacillin, results in less tissue damage and a more rapid resolution of both systemic and local features, in a cost-effective manner. This study is a randomised controlled trial comparing Clindamycin with placebo.
Criteria to be used to assess tissue damage and clinical response: 1. Fever, tachycardia, neutrophil count, urea and other laboratory parameters at five and ten days post first dose of clindamycin 2. Limb swelling (by the measurement of limb circumference), skin surface temperature and tissue damage (by the proportion of the limb affected) 3. Document the duration between initial systemic features and the development of local signs 4. Examine the effect of the duration between systemic and local features and first dose of flucloxacillin on the subsequent duration and severity of cellulitis 5. Examine the effect of duration between the first dose of flucloxacillin and the first dose of clindamycin on the subsequent duration and severity of cellulitis 6. Identify and quantify possible side effects of clindamycin ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02864420 -
Hospitalization at Home: The Acute Care Home Hospital Program for Adults
|
N/A | |
| Completed |
NCT00746109 -
Study of Wound Packing After Superficial Skin Abscess Drainage
|
Phase 4 | |
| Completed |
NCT03296280 -
Evaluation of Implementation of a National Point-of-Care Ultrasound Training Program
|
||
| Not yet recruiting |
NCT01947660 -
Continuous Regional Anesthesia for Septic Limb Orthopedic Surgery
|
N/A | |
| Active, not recruiting |
NCT01706913 -
Study Assessing Impact of Dermatology Consultation for Patients Admitted With Cellulitis
|
N/A | |
| Completed |
NCT03474523 -
Effectiveness of Diathermy-Radiofrecuency Compared With Cavitation in Cellulitis Treatment
|
N/A | |
| Recruiting |
NCT03312946 -
Effect of Vibro-oscillatory Therapy for Improvement of Body Contour and Appearance of Cellulite.
|
N/A | |
| Active, not recruiting |
NCT05226260 -
Decreasing Antibiotic Duration for Skin and Soft Tissue Infection Using Behavioral Economics in Primary Care
|
N/A | |
| Active, not recruiting |
NCT03785834 -
The Effect of Histopathologic Analysis and Tissue Cultures on Inpatient Management of Cellulitis and Pseudocellulitis
|
||
| Completed |
NCT01549613 -
Evaluation of Daptomycin for the Emergency Department Treatment of Complicated Skin and Skin Structure Infections
|
Phase 4 | |
| Completed |
NCT01029782 -
Comparison of Intravenous Cefazolin Plus Oral Probenecid With Oral Cephalexin for the Treatment of Cellulitis
|
Phase 2 | |
| Completed |
NCT00676130 -
Study of New Antibiotic Regimen for the Treatment of Uncomplicated Cellulitis in Emergency Department Patients
|
N/A | |
| Not yet recruiting |
NCT03917134 -
Prevention of Vaginal Cellulitis or Vaginal Cuff Abscess After Laparoscopic Hysterectomy
|
N/A | |
| Completed |
NCT02230813 -
Predictors of Oral Antibiotic Treatment Failure in Emergency Department Patients With Cellulitis
|
N/A | |
| Completed |
NCT01557426 -
Soft Tissue Ultrasound of Infections
|
Phase 1 | |
| Completed |
NCT01339091 -
Efficacy and Safety of Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections
|
Phase 3 | |
| Completed |
NCT00984022 -
Aquacel Versus Iodoform Gauze for Filling Abscess Cavity Following Incision and Drainage
|
Phase 2 | |
| Completed |
NCT04091672 -
RECELL® System Combined With Meshed Autograft for Reduction of Donor Skin Harvesting in Soft Tissue Reconstruction
|
N/A | |
| Completed |
NCT05023200 -
The Personalised Antibiotic Duration for Cellulitis (PAD-C) Study
|
||
| Terminated |
NCT02087527 -
Use of Corticosteroids in Children With Cellulitis
|
N/A |