Clinical Trials Logo
  1. Home
  2. Celiac Disease in Children
  3. NCT05675280
  4. Details
NCT05675280 Clinical Trial

Iron Deficiency and TTG Normalization

Celiac Disease in Children Clinical Trial

Official title:
The Association Between Iron Deficiency at Diagnosis, Female Sex and Tissue Transglutaminase Antibody Normalization in Pediatric Celiac Disease

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05675280
Other study ID # MMC-20-0021
Secondary ID
Status Completed
Phase
First received
Last updated
Start date February 20, 2020
Est. completion date April 1, 2022

Study information
Verified date January 2023
Source Meir Medical Center
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The investigators conducted a retrospective, observational cohort study which enrolled CD subjects aged 2-18y, diagnosed between Jan 2016 and Dec 2020. Demographic and laboratory data were collected at diagnosis and 1y after adherence to GFD. ID was determined according to hemoglobin and ferritin levels. The investigators compared CD subjects with and without ID at CD diagnosis in relation to TTG normalization at 1y.

Recruitment information / eligibility
Status Completed
Enrollment 118
Est. completion date April 1, 2022
Est. primary completion date March 1, 2022
Accepts healthy volunteers No
Gender All
Age group 2 Years to 18 Years
Eligibility Inclusion Criteria: - Children (male and female) diagnosed with CD - Age 2-18y Exclusion Criteria: - Total IgA deficiency - Anemia due to other causes - anyone with anemia and normal or elevated ferritin levels (e.g. thalassemia, spherocytosis) - Other chronic conditions increasing the risk of anemia or falsely elevated ferritin (e.g. inflammatory bowel disease, chronic kidney disease, infection)

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Gluten free diet
All subjects initiated a gluten free diet as mandated by their diagnosis of Celiac disease, regardless of the study

Locations
Country Name City State
Israel Meir medical center Kfar Saba

Sponsors (1)
Lead Sponsor Collaborator
Meir Medical Center

Country where clinical trial is conducted

Israel, 

Outcome
Type Measure Description Time frame Safety issue
Primary TTG normalization normalization of tissue transglutaminase antibody 1 year from gluten free diet initiation
See also
  Status Clinical Trial Phase
Not yet recruiting NCT04440501 - Virtual Reality to Teach, Improve Outcomes, and Engage (VIRTUE): Virtual Reality to Improve Gluten-Free Diet Knowledge in Pediatric Celiac Disease N/A
Enrolling by invitation NCT06179121 - "Adding DNA-test for Screening of HLA-DQ2 and DQ8 to Improve Early Diagnosis of Celiac Disease"
Recruiting NCT06324539 - Validation of a New Innovative Method for Specific Marker Detection in Celiac Disease
Completed NCT06359613 - Efficacy Assessment of Gluten Free Cupcakes N/A
Active, not recruiting NCT05548166 - Development of CELIAC-Q KIDS: A Patient-Reported Outcome Measure for Pediatric Celiac Disease
Recruiting NCT04014660 - Prevention av Autoimmunitet Med Laktobaciller N/A
Not yet recruiting NCT04019223 - Anti-Tissue Transglutaminase IgA Antibodies
Completed NCT03966625 - Serological Identification of Celiac Disease in Kids
Not yet recruiting NCT03244254 - Intestinal Fatty Acid-binding Protein (I-FABP) Levels in Pediatric Celiac Patients N/A
Recruiting NCT05132725 - Carbohydrate Counting and DASH Intervention Among Children With Diabetes and Celiac Disease. N/A
Enrolling by invitation NCT05084937 - Celiac Disease in Childhood-Adulthood Transition N/A
Active, not recruiting NCT04593888 - Gluten Reduction and Risk of Celiac Disease N/A
Recruiting NCT06007898 - Supporting Children and Young People to Live Well With Coeliac Disease N/A
Recruiting NCT06364735 - Entities and Variables Related to Catch-up Growth
Completed NCT04272983 - Population Study of the Prevalence of Celiac Disease and Other Gluten-dependent Disorders in Children and Adolescents
Not yet recruiting NCT06149507 - Effect of Acetaminophen Versus Ibuprofen in Treating Recurrent Apthous Ulcers in Pediatric Celiac Disease Phase 4
Completed NCT04240340 - Experiences of Disclosure in Adolescents With Coeliac Disease
Completed NCT03176095 - Celiac Disease Prevention With Probiotics N/A
Active, not recruiting NCT06038344 - Influence of a Gluten Free Food Guide on Diet Quality and Adherence to the GFD in Youth With Celiac Disease N/A
Completed NCT04533776 - Support for Adolescents With Celiac Disease N/A