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CDK12 Gene Mutation clinical trials

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NCT ID: NCT04030559 Recruiting - Prostate Carcinoma Clinical Trials

Niraparib Before Surgery in Treating Patients With High Risk Localized Prostate Cancer and DNA Damage Response Defects

Start date: February 25, 2020
Phase: Phase 2
Study type: Interventional

This phase II trial studies how well niraparib, when given before surgery, works in treating patients with high risk prostate cancer that has not spread to other parts of the body (localized) and alterations in deoxyribonucleic acid (DNA) repair pathways. Niraparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.