Catatonia Clinical Trial
Official title:
Prospective Treatment Study of Catatonia Patients With Right Unilateral Electroconvulsive Treatment (RUL ECT) and Bilateral Electroconvulsive Treatment (BL ECT) Regimens
Verified date | June 2019 |
Source | Wake Forest University Health Sciences |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this treatment study is to compare the effectiveness of different electrode
placements used in Electroconvulsive Therapy (ECT) in the treatment of catatonia. In this
study Electroconvulsive Therapy will be compared to medications used in the treatment of
catatonia. Medications will be administered by the primary team as part of standard of care.
Medications are not primarily being used as a part of this research study.
This treatments study, will be able to compare response rate of catatonia to right unilateral
electroconvulsive treatment (RUL ECT) and Bilateral electroconvulsive treatment (BL ECT).
Also having a control group of catatonia patients, which will not be treated with ECT will
provide additional information on early ECT treatment of Catatonia.
Status | Terminated |
Enrollment | 2 |
Est. completion date | March 19, 2017 |
Est. primary completion date | March 19, 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 99 Years |
Eligibility |
Inclusion Criteria: - Adult patients admitted to WFBMC Inpatient Psychiatry unit with catatonia who are clinically eligible for ECT. - Clinical catatonia as evidenced by a Bush-Francis Catatonia Rating Scale (BFCRS) score of 4 or more Exclusion Criteria: - Pregnant women Patients with any of the following medical conditions which are contraindications for ECT: - Pheochromocytoma - History of stroke within the past 3 months - Cardiac conduction defects - Cerebral or aortic aneurysms |
Country | Name | City | State |
---|---|---|---|
United States | Wake Forest University Baptist Medical Center | Winston-Salem | North Carolina |
Lead Sponsor | Collaborator |
---|---|
Wake Forest University Health Sciences |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Catatonia on the Bush- Francis Scale (BFCRS) - Pre | Repetitive evaluation by the Bush- Francis Scale (BFCRS) - To assess excitement, immobility, mutism, staring, posturing/catalepsy, grimacing, echopraxia, stereotypy, mannerisms, verbigeration, rigidity, negativism, waxy flexibility, withdrawal, impulsivity, automatic obedience, mitgehen, gegenhalten, ambitendency, grasp reflex, preservation, combativeness and automatic abnormality. Contains 23 items rated using a scale of 0-3. Total Score 0-69. Higher scores denote worse outcomes. | Prior first ECT treatment | |
Primary | Catatonia on the Bush- Francis Scale (BFCRS) - Pre | Repetitive evaluation by the Bush- Francis Scale (BFCRS) - To assess excitement, immobility, mutism, staring, posturing/catalepsy, grimacing, echopraxia, stereotypy, mannerisms, verbigeration, rigidity, negativism, waxy flexibility, withdrawal, impulsivity, automatic obedience, mitgehen, gegenhalten, ambitendency, grasp reflex, preservation, combativeness and automatic abnormality. Contains 23 items rated using a scale of 0-3. Total Score 0-69. Higher scores denote worse outcomes. | 1 day post first ECT treatment | |
Secondary | Depression on the Hamilton Depression Scale | Repetitive evaluation by the Hamilton depression scale - To measure efficacy of ECT | 30 days | |
Secondary | Cognitive Side Effects on Montreal Cognitive Assessment (MoCA) | Repetitive evaluation by the Montreal Cognitive Assessment (MoCA)- To evaluate possible cognitive side effects. | 30 days |
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