Chronic Low Back Pain Clinical Trial
Official title:
The Efficiency of Conditioned Pain Modulation is Associated With Levels of Pain Catastrophizing in Patients With Chronic Low Back Pain
This study evaluates the potential association between pain catastrophizing thoughts and the ability to dampen pain via endogenous descending inhibition. Half of the participants are persons with chronic low back pain and the other half are age and gender-matched controls
Pain catastrophizing is a cognitive feature commonly seen in various musculoskeletal pain
population and is considered an important factor to account for in rehabilitation. The
ability to dampen pain via endogenous pain modulatory mechanisms is likewise known to be
reduced in musculoskeletal pain conditions.
Studies utilizing functional magnetic resonance imaging (fMRI) have demonstrated that the
supraspinal areas involved in pain-related cognitive processing to a great extent overlap
with those involved in endogenous pain modulation. Therefore, it is plausible that factors
such as pain catastrophizing thoughts may affect the nervous systems ability to dampen pain.
Chronic low back pain is the single clinical problem with the biggest impact in the modern
society. Previous studies have demonstrated that pain catastrophizing and reduced endogenous
pain inhibition are part of the clinical picture. However, previous studies have never
investigated a potential relationship between these two factors.
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