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Identification of Potential Biomarkers of Peptide Immunotherapy. Part 2 - Gene Array Analysis

Cat Allergy Clinical Trial

Official title:
Identification of Potential Biomarkers of Peptide Immunotherapy. Part 2 - Gene Array Analysis

Clinical Trial Summary

Cat allergy is an increasingly prevalent condition, affecting 10-15% of patients with allergic rhinoconjunctivitis. Cat-PAD is a novel, synthetic, allergen derived peptide desensitising vaccine currently being developed for treatment of cat allergy.

At present, the efficacy of immunotherapy (peptide or otherwise) can only be established at the conclusion of therapy. No reliable predictive biomarkers of clinical efficacy currently exist. Identification of surrogate biomarkers of clinical efficacy, would facilitate clinical development of peptide immunotherapy vaccines, in addition to providing an improved understanding of the underlying molecular mechanisms of efficacy, thus providing new leads for therapeutic intervention.

Clinical Trial Description

n/a

Study Design

Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01383603
Study type Interventional
Source Circassia Limited
Contact
Status Completed
Phase Phase 1
Start date October 2011
Completion date May 2014
View Details
See also
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Completed NCT00729508 - Effectiveness of Cat-PAD to Treat Cat Allergy in Cat Allergic Subjects Phase 2
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