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Clinical Trial Summary

The study is designed to understand the safety, tolerability, pharmacokinetics, immunogenicity, and preliminary antitumor activity of MGC026 in participants with relapsed or refractory, unresectable, locally advanced or metastatic solid tumors The study has a dose escalation portion and a cohort expansion portion of the study. Participants will receive MGC026 by intravenous (IV) infusion. The dose of MGC026 will be assigned at the time of enrollment. Participants may receive up to 35 treatments if there are no severe side effects and as long as the cancer does not get worse. Participants will be monitored for side effects, and progression of cancer, have blood samples collected for routing laboratory work, and blood samples collected for research purposes.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms

  • Advanced Cancer
  • Advanced Solid Tumor
  • Bladder Cancer
  • Carcinoma
  • Carcinoma, Renal Cell
  • Castration Resistant Prostatic Cancer
  • Cervical Cancer
  • Clear Cell Renal Cell Carcinoma
  • Colorectal Cancer
  • Endometrial Cancer
  • Endometrial Neoplasms
  • Gastric Cancer
  • Gastro-esophageal Cancer
  • Hepatocellular Carcinoma
  • Lung Neoplasms
  • Melanoma
  • Metastatic Cancer
  • Non Small Cell Lung Cancer
  • Pancreas Cancer
  • Pancreatic Neoplasms
  • Platinum-resistant Ovarian Cancer
  • Prostatic Neoplasms
  • Prostatic Neoplasms, Castration-Resistant
  • Sarcoma
  • Small Cell Lung Carcinoma
  • Small-cell Lung Cancer
  • Squamous Cell Carcinoma of Head and Neck

NCT number NCT06242470
Study type Interventional
Source MacroGenics
Contact Global Trial Manager
Phone 301-251-5172
Email info@macrogenics.com
Status Recruiting
Phase Phase 1
Start date March 6, 2024
Completion date October 2028

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