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Cartilage Disease clinical trials

View clinical trials related to Cartilage Disease.

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NCT ID: NCT06238947 Not yet recruiting - Cartilage Injury Clinical Trials

Long-term Outcome Evaluation of Patients Undergoing Autologous Chondrocyte Transplantation Delivered on Biomaterial

Start date: August 2024
Phase:
Study type: Observational

Chondro-Long study is prospective observational study for a long-term clinical evaluation (follow-up up to 25 years) in patients treated with autologous chondrocyte transplantation delivered on biomaterial for full-thickness chondral defects (Outerbridge grade III - IV) at the level of femoral condyles, trochlea, patella and tibial plateau. The aim of the study is to collect long-term clinical data from the case series of patients surgically treated from 1999 to 2006 with autologous chondrocyte transplantation delivered on biomaterial for full-thickness chondral defects (Outerbridge grade III - IV) or osteochondral defects at the level of femoral condyles, trochlea, patella, and tibial plateau. The objective of the study is to demonstrate the efficacy of this long-term cartilage regeneration technique (follow-up up to 25 years) in improving patient symptomatology and functional capacity

NCT ID: NCT05391841 Not yet recruiting - Cartilage Disease Clinical Trials

Non-interventional Study in Pediatric Patients Treated With NOVOCART Inject in the Knee

NINJA
Start date: May 31, 2024
Phase:
Study type: Observational [Patient Registry]

The study is a prospective, multicenter, single-arm non-interventional study to evaluate the efficacy, safety and health economics of NOVOCART® Inject in the treatment of cartilage defects of the knee in pediatric patients with radiologically proven closed epiphyseal growth plates.

NCT ID: NCT04785092 Recruiting - Cartilage Damage Clinical Trials

All Autologous Cartilage Regeneration in the Treatment of the Knee Cartilage Defects

Start date: March 1, 2021
Phase: N/A
Study type: Interventional

The cartilage articular defects of the knee are extremely disabling lesions and represent one of the predisposition causes to the development of articular arthrosis. When clinical symptoms are present, exist the indication to treat the patient surgically, to this end, several surgical techniques could be performed, as the microfractures, osteochondral transplantation (OCT) or chondrocytes autologous transplantation (ACT). The aim of this pilot study is to evaluate the clinical performance of a modified version of the ACT technique, the All Autologous Cartilage Repair technique (AACR). A one-step technique in which the healthy cartilage harvested is fragmented directly in situ and then mixed with the autologous platelet concentrate and directly injected in the cartilage defect.. This lead to a less invasive surgery and cost-effective procedure. The performance will be evaluated through the evaluation of clinical results and complications after surgery other than the evaluation of the quality of the cartilage tissue repaired.

NCT ID: NCT04537013 Recruiting - Knee Injuries Clinical Trials

Clinical Study of Chondro-Gide® for Large Chondral Lesions in the Knee

SECURE
Start date: August 26, 2020
Phase: N/A
Study type: Interventional

Multi-center, prospective, concurrently controlled, non-randomized, double-blind (patient and assessor). Treatment of large chondral lesions in the knee with microfracture plus the Chondro-Gide® ACC is non-inferior to treatment of small chondral lesions treated with microfracture alone.

NCT ID: NCT04186208 Active, not recruiting - Cartilage Disease Clinical Trials

Non-interventional Study With NOVOCART® 3D for the Treatment of Cartilage Defects of the Knee in Pediatric Patients

JUNOVO
Start date: April 25, 2017
Phase:
Study type: Observational

Prospective, multicenter, single-arm non-interventional study to evaluate the efficacy, safety and health economics of NOVOCART 3D in the Treatment fo cartilage defects of the knee in pediatric patients wieh closed epiphyseal growth plates.

NCT ID: NCT02991300 Recruiting - Cartilage Disease Clinical Trials

BioPoly® RS Partial Resurfacing Patella Registry Study

Start date: September 2016
Phase:
Study type: Observational [Patient Registry]

The data registry will increase the knowledge of outcomes for treatment of focal cartilage defects of the patella treated with the BioPoly RS Patella Implant and will allow monitoring of the clinical safety and performance of the device and surgical implantation kit

NCT ID: NCT02941120 Completed - Cartilage Disease Clinical Trials

Non-interventional Study With NOVOCART® Inject in the Reconstruction of the Knee Cartilage Defects

RENOVO
Start date: December 2015
Phase:
Study type: Observational

Retrospective non-interventional study to evaluate safety and efficacy of NOVOCART® Inject in patients with full-thickness cartilage defects in the knee joint.

NCT ID: NCT02179346 Completed - Cartilage Disease Clinical Trials

Observational Study With NOVOCART® Inject in the Reconstruction of the Hip Joint With Full Thickness Cartilage Defects

HIP-ACTION
Start date: December 2014
Phase:
Study type: Observational

Non-interventional study to evaluate safety and efficacy of NOVOCART® Inject in patients with full thickness cartilage defects in the hip.

NCT ID: NCT00961597 Withdrawn - Cartilage Disease Clinical Trials

Assessment of Outcome of Meniscus Repair With or Without Platelet Rich Plasma

Start date: September 2009
Phase: N/A
Study type: Interventional

The purpose of this investigation is to determine the clinical outcome of repair of meniscus tears located in the "red/white" region using a well-known suture technique combined, when indicated, with platelet-rich plasma to enhance healing. The outcome of this operation will be determined in a consecutive group of patients with an established, rigorous knee rating system a minimum of 2 years postoperatively. Results will be determined by the analysis of subjective and functional factors, sports and occupational activity levels, a comprehensive physical examination, and a radiographic evaluation using standard plain x-rays and magnetic resonance imaging. The investigators hypothesize that meniscus repairs will significantly reduce tibiofemoral compartment pain and allow for increased knee function and activity levels. The platelet rich plasma adjunct will be used in complex meniscus tears in which a portion of the tear extends into the avascular region classified as either longitudinal, horizontal, or radial. The investigators hypothesize that the healing rate of these repairs will be superior to those previously reported in clinical studies in patients who had the suture repair technique alone.