Carotid Artery Stenosis Clinical Trial
Official title:
Aortic Calcification - is it a Marker for Carotid Artery Stenosis?
Atherosclerosis is the major contributor for the morbidity and mortality for the variety of
cardiovascular diseases.
Aortic calcification on x-ray is a marker for arterial atherosclerosis and an independent
prognostic factor for the morbidity and mortality from a cardiovascular event.
Carotid artery stenoses is the current accepted indication for interventional treatment of
carotid artery, for the prevention of embolic event, while other arterial atherosclerosis
indication, is for hemodynamic disturbance and ischemic outcome.
This research will try to find whether incidental aortic calcification can predict carotid
artery stenosis.
Two groups will be chosen: group A - patients who had CT scan in the hospital (for different
indications); Group B - patients (not from the first group) who have a significant carotid
artery stenosis who are indicated for interventional treatment.
The data to analyze:
Group A - Patients with aortic calcification, carotid artery stenosis, and patients with
both Group B - Patients who have aortic calcification Comparison of the populations within
the group and among the two will show if a significant correlation between aortic
calcification and carotid artery stenosis exist.
Background - thoracic or abdominal aortic calcification is a documented independent risk
factor for cardiovascular atherosclerotic disease and increased death.
Atherosclerosis is a diffuse multicentric disease in the arterial tree, affecting target
organs (heart, aorta, lower extremities, carotid arteries etc.). Mostly located in arterial
bifurcations (Iliac and carotid artery bifurcations) or in constant repetitive arterial
trauma (Adductors tendon, Hunter's canal). The invasive treatment (endovascular, surgery) is
preserved for patients with critical arterial stenosis or occlusion in symptomatic patients.
Exceptions are the carotid arteries: the majority of patients with a severe internal carotid
artery stenosis are asymptomatic patients, which are treated for the prevention embolic
events (TIA's or CVA's).
Current articles are observational, and describe retrospectively the morbidity and mortality
from atherosclerosis with aortic calcification.
the investigators assumption is that if aortic calcification is a marker for diffuse
atherosclerosis, it has good correlation to criptogenous carotid artery disease, and can
lead to early carotid artery disease evaluation and treatment.
Purpose - to find a reliable correlation between aortic calcification, and carotid artery
stenosis (from atherosclerosis)
Method - two groups will be evaluated:
Group A - patients (age >40 years), that had a CT scan (chest/abdomen) for any indication,
will be evaluated for aortic calcifications. The patients will be additionally examined for
carotid artery stenosis by Doppler ultrasound. (100 patients) Group B - Patients that were
diagnosed by Doppler ultrasound, and were found to have a severe carotid artery stenosis.
These patients are scheduled for a computed tomography-angiography (regardless for the
research) of the cervical arteries, will be additionally complete abdominal/chest tomography
scan, without additional contrast. (50 patients).
Results - will be statistically evaluated - Group A - number of patients with aortic
calcification, number of patients with carotid artery stenosis; Group B - Number of patients
that have associated aortic calcification.
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Observational Model: Case-Crossover, Time Perspective: Prospective
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