Carotid Artery Diseases Clinical Trial
Official title:
Long-term Outcomes of MicroNet-covered Stent Routine Use for Stroke Prevention in Symptomatic and Increased-risk Asymptomatic Carotid Stenosis Patients Requiring Revascularization by Neurovascular Team Decision: PARADIGM-EXTEND
All-comer study of unselected patients suitable for carotid artery revascularization to evaluate the feasibility, efficacy and safety of first line endovascular revasculariztion using MicroNet covered stent (CGuard™) in the treatment of consecutive symptomatic and increased-stroke-risk asymptomatic carotid lesions that require revascularization by Neurovascular Team decision.
Independent investigator initiated, academic, single arm, open-label, non-randomized, prospective, multicenter, multispecialty trial of CGuard™ routine use in all-comer population of consecutive patients with symptomatic or increased-stroke-risk asymptomatic carotid stenosis. Increased-stroke-risk is defined as the following patient and/or lesion characteristics: thrombus containing, documented progressive, irregular, ulcerated lesion; evidence of ipsilateral ischemic cerebral injury in MRI or CT imaging; contralateral stroke in relation to carotid stenosis; contralateral artery occlusion. The main objective of this observational study is to evaluate (1) the periprocedural feasibility and efficacy of CGuard™ stent system in the treatment of carotid artery stenosis (2) long-term efficacy and safety of routine CGuard™ stent system use. The study hypothesis is that the novel CGuard™ MicroNet® covered stent is safe and effective for a majority of consecutive patients considered to require carotid revascularization. The multicenter arm of the project has a specific cohort descriptor: PARADIGM-EXTEND MC ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04632485 -
Early Detection of Vascular Dysfunction Using Biomarkers From Lagrangian Carotid Strain Imaging
|
||
| Completed |
NCT02133807 -
Specific Lp(a) Apheresis for Regression of Coronary and Carotid Atherosclerosis
|
Phase 3 | |
| Completed |
NCT00241787 -
Progression of Sub-Clinical Atherosclerosis
|
N/A | |
| Completed |
NCT00070668 -
Inflammatory Genomics in Human Carotid Artery Disease
|
N/A | |
| Completed |
NCT00035711 -
VA HDL Intervention Trial (VA-HIT) Ancillary Study Data Analysis
|
N/A | |
| Completed |
NCT00005459 -
Risk of Coronary Heart Disease in Women With Polycystic Ovary Syndrome
|
N/A | |
| Completed |
NCT00005479 -
Diabetes, Lipoproteins and Accelerated Vascular Disease
|
N/A | |
| Completed |
NCT00005397 -
Epidemiology of Carotid Artery Atherosclerosis in Youth
|
N/A | |
| Completed |
NCT00005134 -
Strong Heart Study
|
N/A | |
| Completed |
NCT03217214 -
Investigation of Contact Based Method for Diagnosis of Cardiovascular Disease
|
||
| Recruiting |
NCT05455099 -
A Multicenter Study of Ultrafast Pulse Wave Velocity in Obese Chinese Han Adults
|
||
| Recruiting |
NCT06359756 -
Ischemic Postconditioning in Carotid Surgery
|
N/A | |
| Recruiting |
NCT05365490 -
Post-approval Study of Transcarotid Artery Revascularization in Standard Risk Patients With Significant Carotid Artery Disease
|
||
| Recruiting |
NCT04679727 -
The Carotid Artery Multi-modality Imaging Prognostic (CAMP) Study
|
||
| Recruiting |
NCT05845710 -
Direct Access Carotid Artery Stenting Using the Neuroguard IEP System (PERFORMANCE III)
|
N/A | |
| Recruiting |
NCT05574972 -
Timing Carotid Stent Clinical Study for the Treatment of Carotid Artery Stenosis（Timing Trial）
|
N/A | |
| Recruiting |
NCT05572320 -
Platelet Function and Neurological Events
|
||
| Active, not recruiting |
NCT03351127 -
Multicenter Normal Reference Study of Carotid Artery Ultrafast Pulse Wave Velocity (UFPWV)
|
||
| Completed |
NCT04255316 -
Modified Method of Eversion Carotid Endarterectomy in Patients With Extensive Atherosclerotic Disease of Carotid Bifurcation
|
N/A | |
| Completed |
NCT04901000 -
Outcome of LA Versus GA for Staged CEA Prior To CABG
|