Caries Dentalis Clinical Trial
Official title:
Effect of Lozenges Containing Probiotic Lactobacilli on Enamel Demineralization Assed by QLF
Clinical trials in children and adults have suggested that daily consumption of probiotic
lactic acid bacteria can reduce caries risk and caries development in primary teeth in
preschool and stop root caries in the elderly. However, it is not known whether probiotic
bacteria can affect the increased porosity in young permanent teeth in children and
adolescents with many cavities.
It can be difficult to measure the increased porosity of the enamel by tooth decay, but this
can be done using quantitative laser fluorescence (QLF). The method is based on visible
light with a wavelength of 370 nm, addressing enamel. This produces an image consisting of
red and green color tones and the dominant color of the enamel is green. Increased porosity
of the enamel, resulting in a reduction of the auto-fluorescence and the loss (or gain) of
the mineral can be quantified by means of a corresponding software.
The purpose of this study is to investigate the effect of a daily supplement of probiotic
lactic acid bacteria on the loss of mineral in enamel assessed with QLF. The null hypothesis
is that the mineral content will not differ from baseline in either the test group or the
placebo group.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention