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NCT01139827 Clinical Trial

Association Between Framingham Risk Score, hsCRP and Vascular Inflammation: Analysis With 18F-Fluorodeoxyglucose Positron Emission Tomography

Cardiovascular Risk Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01139827
Other study ID # PET(FRS-CRP)
Secondary ID
Status Completed
Phase N/A
First received June 8, 2010
Last updated June 8, 2010
Start date September 2009
Est. completion date February 2010

Study information
Verified date February 2010
Source Korea University Guro Hospital
Contact n/a
Is FDA regulated No
Health authority Korea: Institutional Review Board
Study type Observational

Clinical Trial Summary

Framingham risk score is well known screening tool that detect cardiovascular (CV) risk. But it is not suitable for CV risk in mild risk group. So 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a new imaging technique for detecting vascular inflammation within atherosclerotic plaques and hsCRP is also arising detection tool of CV risk.

The investigators are examining this association in normal and impaired glucose tolerance patients groups.

Description:

We examined vascular inflammation using FDG-PET scan in 178 subjects (Normal and impaired glucose tolerance groups). Vascular 18F-FDG uptake was measured as both the mean and maximum blood-normalized standardized uptake value (SUV), known as the target-to-background ratio (TBR). And We analyzed that the association with Framingham risk score, hs CRP and vascular inflammation by FDG-PET scan.

Recruitment information / eligibility
Status Completed
Enrollment 178
Est. completion date February 2010
Est. primary completion date February 2010
Accepts healthy volunteers No
Gender Both
Age group 16 Years to 80 Years
Eligibility Inclusion Criteria:

- healthy subjects

Exclusion Criteria:

- a history of cardiovascular disease (myocardial infarction, unstable angina, stroke or cardiovascular revascularization)

- active inflammatory disease, recent active infection

- stage 2 hypertension (resting blood pressure, = 160/100 mmHg)

- diabetes mellitus

- systemic disorders such as severe hepatic, renal, and hematologic diseases

- taking drugs known to interfere with vascular inflammation measured by FDG-PET.

Study Design

Observational Model: Cohort, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Locations
Country Name City State
Korea, Republic of Korea university guro hospital Seoul

Sponsors (1)
Lead Sponsor Collaborator
Korea University Guro Hospital

Country where clinical trial is conducted

Korea, Republic of, 

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