Clinical Trials Logo
  1. Home
  2. Cardiovascular Risk Factors
  3. NCT05334888

Sex-differential Host-microbiome CVD Risk - A Longitudinal Cohort Approach — XCVD  

Cardiovascular Risk Factors Clinical Trial

Official title:
Sex Hormone-specific Cardiovascular Risks in the Gut Microbiome-host Axis - A Longitudinal Cohort Study.

Clinical Trial Summary

The XCVD study investigates the influence of sex hormones on the composition of the gut microbiome and the possible emergence of cardiovascular risk factors. It will follow 200 healthy transgender individuals for two years during their hormone replacement therapy (HRT) and analyze them for the possible emergence of cardiovascular risk factors in relation to changes in the gut microbiome, metabolome, and immunome. We would also like to phenotype cardiovascular disease.

Clinical Trial Description

Conducting this innovative study using established scientific methods such as omics platforms, systems biology, and careful CVD phenotyping will allow, for the first time, extensive data collection on the influence of sex hormones on the development of CVD risk factors as well as the role of the gut microbiome. In doing so, the influence of circulating sex hormones can also be quantified to potentially predict CVD risk markers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05334888
Study type Observational [Patient Registry]
Source Charite University, Berlin, Germany
Contact Sofia Forslund, Prof. Dr.
Phone +49 30 450540649
Email sofia.forslund@mdc-berlin.de
Status Recruiting
Phase
Start date August 29, 2022
Completion date December 31, 2027
View Details
See also
  Status Clinical Trial Phase
Completed NCT02589769 - Effects of Reduction in Saturated Fat on Cholesterol and Lipoproteins in Lean and Obese Persons N/A
Recruiting NCT01902654 - Osteoarthritis Cardiovascular Risk Factors N/A
Completed NCT01698034 - Volunteering and Cardiovascular Risk in Adolescents N/A
Recruiting NCT01231152 - The Impact of Obesity on Children and Adolescents. N/A
Completed NCT00983333 - Initial Test of the Time to Talk CARDIO (Creating a Real Dialogue In the Office) Program N/A
Terminated NCT00527436 - Fish Oil and Biomarkers of Cardiovascular Risk N/A
Recruiting NCT02917928 - The Potential of Carnosine Supplementation in Optimising Cardiometabolic Health Phase 2
Active, not recruiting NCT02490683 - Effects of Soy Based Dietary Supplements on Cardiometabolic Risk Factors. N/A
Recruiting NCT02282748 - Swiss Longitudinal Cohort
Completed NCT01252316 - Cardiopulmonary Resuscitation (CPR) Dissemination Study Using Nurses and Volunteers Phase 1/Phase 2
Completed NCT01190592 - Resistance Training With Milk Supplementation in Adolescents N/A
Completed NCT00787306 - Cardiovascular Health And Risk Modification in Family Health Teams Phase 3
Withdrawn NCT01087411 - Intervention Study to Prevent Obesity in Sedentary 8 Year Old Swedish Children N/A
Completed NCT01260441 - An In-Hospital Family Member Cardiopulmonary Resuscitation (CPR) Education Program Phase 1
Completed NCT04025463 - Healing Our Hearts Minds and Bodies: CVD Reduction in Persons With HIV N/A
Completed NCT02922920 - Effects of Tart Cherry Juice on the Body N/A
Completed NCT01514656 - CPR Training: Video Self-Instruction Kit or Video-Only N/A
Completed NCT01134029 - Planned CORR: Planned Care for Obesity and Risk Reduction N/A
Active, not recruiting NCT00786890 - A Survey to Evaluate the Cardiovascular Risk Status of Subjects With Pre-Diabetes in Hong Kong N/A
Completed NCT00882336 - European Study of Cardiovascular Risk N/A