Autonomic Nervous System Clinical Trial
Official title:
Impact of Caffeine Intake Before Exercise on the Neural Regulation of the Cardiovascular System in Physically Active Adults
The objective of this study was to evaluate the variability of the heart rate of exercise physicists with and without caffeine intake. Practitioners of resisted physical exercise, specifically bodybuilding, who are young adults between the ages of 18 and 30 will participate in the study. To define the sample size, a sample calculation was performed based considering as variable the RMSSD index (square root of the square mean of the differences between the adjacent normal iRRs). The significant difference magnitude assumed was 12 ms, considering a standard deviation of 16.2 ms, with alpha risk of 5% and beta of 80%. A minimum of 14 subjects per group were required in the survey. A total of 32 subjects will participate in the research, being these divided and allocated in different groups. Sampling will be of the intentional kind.
Caffeine supplementation has been studied in several sports modalities with the objective of
investigating its repercussions on athletes' physical performance. Caffeine may lead to an
obstruction of adenosine receptors (A1 and A2) and increase the activity of the Autonomic
Nervous System (ANS) by releasing catecholamines in plasma, inducing tachycardia and
elevating blood pressure. Such modulation of nervous system activity can be traced by
assessing heart rate variability (HRV). HRV is one of the most practical methods to analyze
the physiological functioning of ANS, both in pathological conditions of the individual and
in the induction of other variables, being a noninvasive measure of cardiac autonomic
modulation markers that analyzes the peak-R intervals a peak-R (RRI) of consecutive
heartbeat. The objective of this study was to evaluate the variability of the heart rate of
exercise physicists with and without caffeine intake. Practitioners of resisted physical
exercise, specifically bodybuilding, who are young adults between the ages of 18 and 30 will
participate in the study. To define the sample size, a sample calculation was performed based
considering as variable the RMSSD index (square root of the square mean of the differences
between the adjacent normal iRRs). The significant difference magnitude assumed was 12 ms,
considering a standard deviation of 16.2 ms, with alpha risk of 5% and beta of 80%. A minimum
of 14 subjects per group were required in the survey. A total of 32 subjects will participate
in the research, being these divided and allocated in different groups. Sampling will be of
the intentional kind.
The expected benefits with the result of this research are to instigate the creation of new
lines of research in this context, being able to intervene in a more effective way in
practitioners of physical exercise of strength, with the possibility of prevention to the
autonomic alterations that are associated with the consumption of stimulant supplements, such
as caffeine, and its consequences on the cardiovascular system.
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