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Investigating Cardiovascular Adverse Events Related to Cancer Treatment — InvestiCAT  

Cardiovascular Morbidity Clinical Trial

Official title:
Investigating Cardiovascular Adverse Events Related to Cancer Treatment: a Study of Extreme Toxicity Using Induced Pluripotent Stem Cells

Clinical Trial Summary

Cisplatin, anthracyclines, bleomycin and trastuzumab can cause severe cardiovascular or pulmonary toxicity. Why some patients are susceptible to extreme toxicity of cancer treatment is largely unknown. Unraveling extreme cardiovascular toxic responses in cancer patients may help understand the pathophysiology of cardiovascular toxicity of these agents and help in understanding the more subtle, long-term cardiovascular side effects that affect a larger part of cancer survivors. With induced pluripotent stem cells we will obtain patient-derived cells to recapitulate and mimic and study pathological (cardiovascular) responses and (cardiovascular) toxicity in vitro.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03199300
Study type Observational
Source University Medical Center Groningen
Contact J.A. Gietema, MD, PhD
Phone +31 50 3612821
Email j.a.gietema@umcg.nl
Status Recruiting
Phase
Start date December 12, 2017
Completion date January 2025
View Details
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