Cardiotoxicity of Aluminum Phosphide Poisoning; Tropinin and CKmb as Early Biomarkers

Cardiotoxicity Clinical Trial

Official title:

Cardiotoxicity of Aluminum Phosphide Poisoning; Biochemical and Electrophysiological Studies and the Utility of Tropinin and CKmb as Early Biomarkers

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT04191265
• Other study ID #: cardiotoxicity of ALP cases
• Status: Active, not recruiting
• Start date: December 5, 2019
• Est. completion date: June 5, 2020

Study information

• Verified date: May 2020
• Source: Assiut University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Aluminum phosphide (AlP) or rice tablet is a cheap pesticide. When it comes in contact with acid (gastric acid) or moisture, it releases phosphine (PH3) gas. The heart,lungs, liver are the main targets in acute Aluminum phosphide (AlP) poisoning. Most deaths occur due to cardiovascular toxicity.

Description:

Aluminium phosphide is a potent respiratory chain enzyme inhibitor. Its most important effect is the inhibition of cytochrome c oxidase. The inhibition of cytochrome c oxidase and other enzymes leads to the generation of superoxide radicals and cellular peroxides , and subsequent cellular injury through lipid peroxidation and other oxidant mechanisms. It stimulates the production of hydrogen peroxide and reactive oxygen species, malonyldialdehyde (MAD), increases superoxide dismutase and inhibits catalase, peroxidase and glutathione . Oxidative stress is one of the main mechanisms of action of aluminium phosphide toxicity

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 60
• Est. completion date: June 5, 2020
• Est. primary completion date: June 5, 2020
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria: ALP poisoned cases

• admitted with free ECG

Exclusion Criteria:

concomitant ingesion of other drugs or toxins

-

Related Conditions & MeSH terms

• Aluminum Phosphid Poisoning
• Cardiotoxicity
• Poisoning

Intervention

Diagnostic Test:
• serum tropinin, serum CKmb
early detection of myocardial injury, allowing application of acute cardiac shock and cardiogenic shock

Locations

Country	Name	City	State
Egypt	Doaa	Assiut

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	assess serum tropinin and CKmb as biomarkers for early detection of ALP induced myocardial injury	assess serum tropinin and CKmb as biomarkers for early detection of ALP induced myocardial injury	6 months