Effect of Indoor Plants on Cardiopulmonary System

Cardiopulmonary Clinical Trial

Official title:

Effect of Indoor Plants on Cardiopulmonary System: a Randomized, Crossover, Controlled Trial

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06060145
• Other study ID #: 20230922-4
• Status: Not yet recruiting
• Phase: N/A
• Start date: October 16, 2023
• Est. completion date: January 13, 2024

Study information

• Verified date: October 2023
• Source: Zhejiang Chinese Medical University
• Contact: Lina Zhang, Ph.D
• Phone: +8618540103321
• Email: zhanglina[@]zcmu.edu.cn
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This is a randomized controlled human exposure crossover study, aims to explore the health benefits of indoor plants on cardiopulmonary system on adults.

Description:

The researchers will conduct a randomized cross-controlled trial involving 48 healthy adults in Hangzhou, China. These participants will be randomly assigned into two groups, each comprising 24 individuals. Each participant will undergo two separate exposures in an office setting: one exposure without any plants present, and another exposure with 34 to 38 potted plants. A washout period of at least 4 weeks will be implemented between the two exposures. Questionnaires, physical examinations and the collection of biological samples will be conducted prior to exposure and after exposure. In addition, the monitoring of negative air ion, air pollutants and noise exposure, as well as collection of environmental microbial samples, will be conducted on weekdays. Researchers will gather samples of blood, urine, nasal secretion, and exhaled breath condensate from participants.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 48
• Est. completion date: January 13, 2024
• Est. primary completion date: January 13, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Living in Hangzhou during the study period;
• Non-smoking, no history of alcohol or drug abuse;
• Staying indoors in daytime we required.

Exclusion Criteria:

• Current or ever smokers;
• Subjects with allergic disease, such as allergic rhinitis, allergic asthma, and atopy;
• Subjects with cardiovascular disease, such as congenital heart disease, pulmonary heart disease, and hypertension;
• Subjects with respiratory disease, such as asthma, chronic bronchitis, and chronic obstructive pulmonary disease;
• Subjects with chronic disease, such as diabetes, chronic hepatitis, and kidney disease;
• Subjects with a history of major surgery;
• Medication use or dietary supplements intake in recent two months;
• Unable to cooperate with follow-up.

Related Conditions & MeSH terms

• Cardiopulmonary

Intervention

Other:
• Plants placed in an office environment
The intervention group will be provided with an intervention consisting of 34-38 potted plants arranged in an office environment for a duration of 8 hours (09:00-17:00) on weekdays (Monday to Friday) for 4 weeks.
• Devoid of any plant presence in an office environment
Participants assigned to the control group will be exposed to an office environment devoid of any plant presence for a duration of 8 hours (09:00-17:00) on weekdays (Monday to Friday) for 4 weeks.

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Lina Zhang	Zhejiang Chinese Medical University

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	C-reactive protein(CRP)	We plan to measure serum concentrations of C-reactive protein(CRP)	Baseline and after 4 weeks plants exposure in first stage, and after washout period, baseline and after 4 weeks plants exposure in second stage.
Other	Interleukin-6(IL-6)	We plan to measure the serum concentrations of Interleukin-6	Baseline and after 4 weeks plants exposure in first stage, and after washout period, baseline and after 4 weeks plants exposure in second stage.
Other	Tumor necrosis factor-a(TNF-a)	We plan to measure the serum concentrations of Tumor necrosis factor-a	Time Frame: Baseline and after 4 weeks plants exposure in first stage, and after washout period, baseline and after 4 weeks plants exposure in second stage.
Primary	Forced Vital Capacity(FVC)	We plan to measure forced vital capacity (FVC) of lung function.	Baseline and after 4 weeks plants exposure in first stage, and after washout period, baseline and after 4 weeks plants exposure in second stage.
Secondary	Blood Pressure(BP)	We plan to measure systolic blood pressure (SBP) and diastolic blood pressure (DBP).	Baseline and after 4 weeks plants exposure in first stage, and after washout period, baseline and after 4 weeks plants exposure in second stage.
Secondary	Heart Rate Variability(HRV)	We plan to measure Heart Rate Variability (HRV).	Baseline and after 4 weeks plants exposure in first stage, and after washout period, baseline and after 4 weeks plants exposure in second stage.