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NCT00500825 Clinical Trial

Influence of Therapeutic Hypothermia on Resting Energy Expenditure

Cardiopulmonary Resuscitation Clinical Trial

Official title:
Influence of Therapeutic Hypothermia on Resting Energy Expenditure in Patients After Cardiopulmonary Resuscitation

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00500825
Other study ID # 486/2003
Secondary ID
Status Completed
Phase N/A
First received July 11, 2007
Last updated May 15, 2008
Start date July 2005
Est. completion date May 2008

Study information
Verified date May 2008
Source Medical University of Vienna
Contact n/a
Is FDA regulated No
Health authority Austria: Ethikkommission
Study type Observational

Clinical Trial Summary

The purpose of this study is the evaluation of the influence of therapeutic hypothermia on resting energy expenditure (REE) in patients after cardiopulmonary resuscitation (CPR). We hypothesized that hypothermia would reduce resting energy expenditure in these patients.

Description:

Therapeutic hypothermia improves neurologic outcome in patients after cardiopulmonary resuscitation (CPR) because of cardiac arrest. In the present study patients will be cooled to 33 degree Celsius after CPR for 24h. To avoid shivering patients will be analgosedated and medically paralysed. Analgosedation and relaxation have already shown to reduce oxygen consumption up to 20 % in critically ill patients.

In patients with brain injury, who were cooled to 33 degree Celsius using a cooling meadow REE could be significantly reduced. In critically ill patients with pyrexia cooling using a cooling meadow REE could be reduced. Oxygen consumption was reduced about 14,7% per degree Celsius.

So far no studies evaluating influence of therapeutic hypothermia on REE in patients after CPR have been published. Therefore we plan to measure REE in 25 cooled patients after CPR using indirect Calorimetry (Deltatrac II Metabolic Monitor, Datex Instrumentarium, Helsinki, Finland).

Recruitment information / eligibility
Status Completed
Enrollment 25
Est. completion date May 2008
Est. primary completion date March 2008
Accepts healthy volunteers No
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- St.p. CPR

- Indication for therapeutic hypothermia for 24h (33 degrees Celsius)

Exclusion Criteria:

- Contraindication for therapeutic hypothermia

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Intervention

Procedure:
• Measurement of Resting Energy Expenditure
Non-invasive measurement of Resting Energy Expenditure

Locations
Country Name City State
Austria Medical University Vienna Vienna

Sponsors (1)
Lead Sponsor Collaborator
Medical University of Vienna

Country where clinical trial is conducted

Austria, 

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