Cardiopulmonary Bypass Clinical Trial
Official title:
The Dose Effect of Activated Clotting Time and Tranexamic Acid on Bleeding in Adult Cardiac Surgery
The goal of this clinical trial is to the dose effect of tranexamic acid and the level of ACT on bleeding in adult cardiac surgery. The main questions it aims to answer are: 1. Does higher dose of tranexamic acid reduce the amount of bleeding and blood transfusion? 2. Does lower ACT level during cardiac surgery reduce the amount of bleeding and blood transfusion? Participants will divided into four groups which have different tranexamic acid dose and ACT level during cardiac surgery to see if there is any different in the amount of bleeding and blood transfusion.
This study is going to analyze the medical records of patients who underwent cardiac surgery between December 1, 2023, and December 31, 2026. The investigators will categorize patients into four groups based on anticoagulation indices (ACT 400-600 seconds; ACT > 600 seconds) and tranexamic acid dosages (low dose; high dose) within the range considered safe for CPB. The primary outcome will be the volume of postoperative bleeding within 24 hours for each group. The findings of this study will contribute to the existing clinical evidence and provide insights for the monitoring and pharmacological management in cardiac surgery. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04084301 -
Impact of Cardiopulmonary Bypass Flow on Renal Oxygenation, Blood Flow and Tubular Injury
|
N/A | |
| Completed |
NCT04062396 -
Comparison of Remowell 2 and Inspire on Delirium and Cognitive Dysfunction
|
N/A | |
| Completed |
NCT02518087 -
Increased Adsorption Membranes During Cardiopulmonary Bypass
|
N/A | |
| Recruiting |
NCT01231776 -
Acupuncture Improves Sleep in Patients Undergoing Cardiopulmonary Bypass
|
N/A | |
| Completed |
NCT00747331 -
Fenoldopam and Splanchnic Perfusion During Cardiopulmonary Bypass
|
Phase 4 | |
| Terminated |
NCT00176657 -
The Use of HEMOBAG to Salvage Blood After Cardiac Surgery
|
Phase 2 | |
| Completed |
NCT00161733 -
Safety and Hemostatic Efficacy of Fibrin Sealant Vapor Heated, Solvent/Detergent Treated (FS VH S/D) Compared With Currently Licensed TISSEEL VH Fibrin Sealant in Subjects Undergoing Cardiac Surgery
|
Phase 3 | |
| Completed |
NCT05525195 -
Influence of Preop Fibrinogen on Blood in Pediatric Cardiac Surgery
|
||
| Completed |
NCT05537168 -
Bayesian Networks in Pediatric Cardiac Surgery
|
||
| Completed |
NCT04238806 -
Desflurane,Brain Natriuretic Peptide and Cardiac Surgery
|
N/A | |
| Completed |
NCT00981474 -
Cerebral Autoregulation Monitoring During Cardiac Surgery
|
N/A | |
| Recruiting |
NCT05588011 -
Influence of Oxygenator Selection on Platelet Function and Rotational Thromboelastometry Following Cardiopulmonary Bypass
|
N/A | |
| Completed |
NCT02566733 -
Minto Model in Effect Site Mode for Target-Controlled Infusion of Remifentanil During Cardiopulmonary Bypass
|
Phase 4 | |
| Terminated |
NCT00385450 -
Cardiopulmonary Bypass-Induced Lymphocytopenia and the Potential Effects of Protease Inhibitor
|
Phase 1 | |
| Completed |
NCT00246740 -
Protection of the Heart With Doxycycline During Coronary Artery Bypass Grafting
|
Phase 2 | |
| Not yet recruiting |
NCT05075265 -
Pharmacokinetics of Methadone in Adults Undergoing Cardiac Surgery With Extracorporeal Circulation
|
||
| Recruiting |
NCT04296071 -
Neutrophil Phenotypic Profiling and Acute Lung Injury in Patients After Cardiopulmonary Bypass (CPB)
|
||
| Completed |
NCT05579964 -
The Role of Dexmedetomidine as Myocardial Protector in Pediatric Cardiac Surgery Total Correction of Tetralogy of Fallot
|
Phase 2/Phase 3 | |
| Active, not recruiting |
NCT04133740 -
Oxygenation Targets in Cardiac Surgery Patients - a Before-and-after Study
|
Phase 4 | |
| Completed |
NCT05033236 -
Platelets and Complement Activation in Coronary Artery Bypass Graft Surgery (CABG)
|