Two Monitors for Measuring the Activated Clotting Time: A Comparison

Status Completed

Clinical Trial Summary

In this observational study a comparison is made between two different monitors for measurement of the activated clotting time (ACT): mechanical versus biochemical techniques

Clinical Trial Description

The ACT is a functional test influenced by multiple factors, such as platelet function, coagulation factors, temperature and contact activation inhibitors. Results produced by different monitors are also prone to vary influenced by the specific method employed to perform the test. The present clinical study aims to compare two types of ACT monitors: the Hemostatic Management System Plus (Medtronic) and i-STAT (Abbott) in 20 cardiac surgical patients by performing five intraoperative consecutive measurements using anti factor Xa as a reference for the actual heparin concentration. Inclusion criteria comprised patients aged 20-80 years, scheduled for coronary bypass surgery. Measurements: 1) before induction of anaesthesia 2 ) after heparin bolus 3) rewarming of the patient 4) weaning from cardiopulmonary bypass 5) after protamine administration. The Hemostatic System Plus ACT monitor served as reference for dosing of heparin in all patients. The study protocol did not intervene with the standard protocol used for anticoagulation. No patient interventions were made. It is hypothesised that the i-STAT ACT monitor has a better correlation with the actual heparin concentration than the Hemostatic Management System Plus ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03203148
Study type	Observational
Source	Umeå University
Contact
Status	Completed
Phase
Start date	April 18, 2017
Completion date	November 1, 2017

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04084301` - Impact of Cardiopulmonary Bypass Flow on Renal Oxygenation, Blood Flow and Tubular Injury	N/A
Completed	`NCT04062396` - Comparison of Remowell 2 and Inspire on Delirium and Cognitive Dysfunction	N/A
Completed	`NCT02518087` - Increased Adsorption Membranes During Cardiopulmonary Bypass	N/A
Recruiting	`NCT01231776` - Acupuncture Improves Sleep in Patients Undergoing Cardiopulmonary Bypass	N/A
Completed	`NCT00747331` - Fenoldopam and Splanchnic Perfusion During Cardiopulmonary Bypass	Phase 4
Terminated	`NCT00176657` - The Use of HEMOBAG to Salvage Blood After Cardiac Surgery	Phase 2
Completed	`NCT00161733` - Safety and Hemostatic Efficacy of Fibrin Sealant Vapor Heated, Solvent/Detergent Treated (FS VH S/D) Compared With Currently Licensed TISSEEL VH Fibrin Sealant in Subjects Undergoing Cardiac Surgery	Phase 3
Completed	`NCT05525195` - Influence of Preop Fibrinogen on Blood in Pediatric Cardiac Surgery
Completed	`NCT05537168` - Bayesian Networks in Pediatric Cardiac Surgery
Completed	`NCT04238806` - Desflurane,Brain Natriuretic Peptide and Cardiac Surgery	N/A
Completed	`NCT00981474` - Cerebral Autoregulation Monitoring During Cardiac Surgery	N/A
Recruiting	`NCT05588011` - Influence of Oxygenator Selection on Platelet Function and Rotational Thromboelastometry Following Cardiopulmonary Bypass	N/A
Completed	`NCT02566733` - Minto Model in Effect Site Mode for Target-Controlled Infusion of Remifentanil During Cardiopulmonary Bypass	Phase 4
Terminated	`NCT00385450` - Cardiopulmonary Bypass-Induced Lymphocytopenia and the Potential Effects of Protease Inhibitor	Phase 1
Completed	`NCT00246740` - Protection of the Heart With Doxycycline During Coronary Artery Bypass Grafting	Phase 2
Not yet recruiting	`NCT05075265` - Pharmacokinetics of Methadone in Adults Undergoing Cardiac Surgery With Extracorporeal Circulation
Recruiting	`NCT04296071` - Neutrophil Phenotypic Profiling and Acute Lung Injury in Patients After Cardiopulmonary Bypass (CPB)
Completed	`NCT05579964` - The Role of Dexmedetomidine as Myocardial Protector in Pediatric Cardiac Surgery Total Correction of Tetralogy of Fallot	Phase 2/Phase 3
Active, not recruiting	`NCT04133740` - Oxygenation Targets in Cardiac Surgery Patients - a Before-and-after Study	Phase 4
Completed	`NCT05033236` - Platelets and Complement Activation in Coronary Artery Bypass Graft Surgery (CABG)