New Horizons for the Treatment of Cardiomyopathy in Children

Status Completed

Clinical Trial Summary

Collecting mono nuclear cells from the patient's blood after a course of granulocyte stimulation then injecting them into the weak heart muscle measuring the heart function at the beginning and after 2.4.6 months to assess the improvement due to this procedure, by comparing these patients to patients with the same condition treated the classic way.

Clinical Trial Description

Dilated cardiomyopathy in children has high morbidity and mortality, current treatment doesn't improve the prognosis and the only cure available is heart transplantation which is limited, has long waiting list (if available), high cost, and has many side effects, leading to the need of novel effective, less costly therapeutic alternatives. Stem cell therapy has proven to improve the cardiac function, reverse the pathologic histological changes, decrease the morbidity and mortality, offering a possible replacement to heart transplantation, different reports proved the safety and efficacy of this therapy using different types of cells and different routs of application in cardiomyopathy and acute myocardial infarction in children and adults, and in congenital heart disease, but the published cases of this therapy conducted on children with dilated cardiomyopathy are scanty . ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04893629
Study type	Interventional
Source	Damascus University
Contact
Status	Completed
Phase	N/A
Start date	May 20, 2021
Completion date	October 30, 2022

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05371496` - Cardiac and Metabolic Effects of Semaglutide in Heart Failure With Preserved Ejection Fraction	Phase 2
Completed	`NCT02892448` - Cardiac MRI for Metal on Metal Hip Resurfacing	N/A
Active, not recruiting	`NCT02537782` - Myocardial Work and Metabolism in CRT	N/A
Completed	`NCT02525185` - Contractile Reserve in Dyssynchrony: A Novel Principle to Identify Candidates for Cardiac Resynchronization Therapy
Terminated	`NCT01705509` - The Effects of Ranolazine on CPET Parameters in Ischemic Cardiomyopathy Patients (ERIC)	N/A
Completed	`NCT00999947` - Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy	N/A
Completed	`NCT00626028` - Comparison of Inhaled Nitric Oxide and Oxygen in Participants Reactivity During Acute Pulmonary Vasodilator Testing	Phase 3
Recruiting	`NCT00138931` - Genetics of Cardiovascular and Neuromuscular Disease
Withdrawn	`NCT02838355` - Employing End Tidal Capnography in Continuous Flow Ventricular Assist Device Patients	N/A
Completed	`NCT01085955` - Investigation in Pregnancy Associate Cardiomyopathy	N/A
Withdrawn	`NCT00428103` - Effects of Mitral Valve Repair With the Geoform Ring on Cardiomyopathy	N/A
Recruiting	`NCT00273637` - Registry and Survey of Women With Pregnancy Related Cardiomyopathy	N/A
Completed	`NCT00810550` - Carotid Ultrasound in the Evaluation of Heart Failure	N/A
Completed	`NCT04603521` - Patients' Long-Term Survival of Obstructive Hypertrophic Cardiomyopathy (HCM)
Enrolling by invitation	`NCT03057561` - Efficacy of Dotarem® (Gd-DOTA) Versus Gadovist® (Gd-DO3A-butrol) for Late Gadolinium Enhancement Cardiac Magnetic Resonance	N/A
Completed	`NCT00027170` - Technical Development of Cardiovascular Magnetic Resonance Imaging
Not yet recruiting	`NCT02917395` - Evaluate the Efficacy of Disopyramide Therapy in Hypertrophic Obstructive Cardiomyopathy Patients	N/A
Completed	`NCT02270840` - Budapest Upgrade CRT Study (Version 009-4.1)	N/A
Completed	`NCT02331264` - Cardiac Assessment of Patients With Hip Implants	N/A
Completed	`NCT02164721` - Multicenter Automatic Defibrillator Implantation Trial - Chemotherapy-Induced Cardiomyopathy	N/A