Cardiomyopathy Clinical Trial
Official title:
CRM and Fusion Beats: Effects of Progressive Fusion on Intra-left Ventricular Mechanical Function
This study is looking at cardiac rhythm management (CRM) and fusion beats in patients who
have a pacemaker or implantable cardioverter-defibrillator (ICD), to determine if there is a
correlation between the time between the contraction of the upper chambers of the heart
(atrium) and the lower chambers of the heart, (ventricle) and heart function.
Some studies of people with pacemakers have been done to determine if shortening the time of
contraction between the atrium and ventricle could benefit the function of the left
ventricle. These studies have shown that there is no benefit in heart function.There have
been other studies which have shown that chronic pacing of the right ventricle, especially
with the lead placed at the tip of the right ventricle, can lead to a decrease in the
function of the left ventricle and congestive heart failure. In some patients long term
pacing of the right ventricle has also been associated with a reduction in the ability of
the left ventricle to pump blood. This is know as a reduced left ventricular ejection
fraction, which can be documented by an echocardiogram.
This study proposes to evaluate the acute effects of progressive paced fusion beats on the
left ventricle to answer the question whether there is an delay between the atrium and
ventricle that is "too long" or "too short".
n/a
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