Clinical Trials Logo

Clinical Trial Summary

The purpose of this study is to determine if LCZ696 is safe, tolerable and can improve exercise capacity (via improved peak VO2) in non-obstructive HCM patient population over the course of 50 weeks of treatment.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04164732
Study type Interventional
Source Novartis
Contact
Status Completed
Phase Phase 2
Start date January 8, 2020
Completion date August 22, 2023

See also
  Status Clinical Trial Phase
Completed NCT00253682 - Effects of Highly Active Anti-Retroviral Therapy on Cardiovascular Health in Infants of HIV-Infected Mothers N/A
Recruiting NCT06034405 - Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis
Terminated NCT04222101 - Association of Insulin Resistance and FGF21 on Cardiac Function in Pediatric Dilated Cardiomyopathy N/A
Recruiting NCT05646056 - A Noninterventional, Single-Center Feasibility Study to Evaluate Measures of Heart Failure Risk
Completed NCT00692991 - Using Magnetic Resonance Imaging to Evaluate Heart Vessel Function After Angioplasty or Stent Placement Procedures N/A
Withdrawn NCT04905173 - Comparison of Squat-to-Stand Maneuver With Amyl Nitrite, Valsalva, and Exercise Stress Echocardiography in Inducing Latent Left Ventricular Outflow Obstruction in Hypertrophic Cardiomyopathy N/A
Recruiting NCT03251287 - Nitrite in Hypertrophic Cardiomyopathy (HCM) Study Phase 1
Recruiting NCT01165749 - Exercise Study Including Patients With Hypertrophic Cardiomyopathy N/A
Recruiting NCT03057002 - UTSW HP [13-C] Pyruvate Injection in HCM
Recruiting NCT02696135 - The Chinese Hypertrophic Cardiomyopathy Study(CHCS)
Recruiting NCT03040947 - MRI Sequence and Imaging Protocol Development
Active, not recruiting NCT02417311 - Individualized Early Risk Assessment for Heart Diseases
Completed NCT03225001 - PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - Nested Registry 3/Valve-in-Valve N/A
Recruiting NCT05524077 - Catheter Ablation Versus Anti-arrhythmic Drugs for Ventricular Tachycardia N/A
Recruiting NCT06112743 - A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy Phase 4
Completed NCT00001871 - Study of Muscle Abnormalities in Patients With Specific Genetic Mutations N/A
Completed NCT00001459 - Analysis of Heart Muscle Function in Patients With Heart Disease and Normal Volunteers N/A
Completed NCT00005251 - Genetic Analysis of Familial Hypertrophic Cardiomyopathy N/A
Active, not recruiting NCT05556343 - A Study to Evaluate the Efficacy, Safety, and Tolerability of MYK-224 in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy Phase 2
Completed NCT03450252 - Pacemaker Therapy for Drug-refractory Symptoms in Mid-cavity Hypertrophic Cardiomyopathy N/A