Nitrite in Hypertrophic Cardiomyopathy (HCM) Study

Status Recruiting

Clinical Trial Summary

Inorganic nitrate, which is found at high levels in green leafy vegetables, is reduced to nitrite by bacteria in the mouth, swallowed, and absorbed in the stomach into the blood. Studies have shown that increasing the blood levels of nitrite improves the way that muscles use oxygen and energy during exercise, and potentially blood flow.

Some people (~1 in 500) suffer from a type of genetic heart condition known as hypertrophic cardiomyopathy (HCM). This condition means that the muscle in the heart does not use energy well and becomes larger than average, meaning that they have to tap into the heart's 'energy reserves'. It is not known if nitrite has the same beneficial effects on heart muscle as on other muscles in the body. Our study will explore the mechanism by which nitrite may improve the function and energy status of the heart in HCM.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03251287
Study type	Interventional
Source	University of East Anglia
Contact	Brodie L Loudon, MBBS
Phone	44(0) 1603 591 216
Email	b.loudon@uea.ac.uk
Status	Recruiting
Phase	Phase 1
Start date	November 2017
Completion date	January 2019

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