Cardiometabolic Risk Clinical Trial
Official title:
Effects of Mixed Spices on Cardiometabolic Function - the PolySPice (PSP) Study
The study will investigate whether having mixed spices rich in polyphenols can improve postprandial cardiometabolic response in healthy Chinese men.
Spices have been used for centuries to enhance food flavouring and to maintain health. Use of
spices as a culinary ingredient is common amongst people of all ethnicities within South and
East Asia. Spices are also one of the main sources of polyphenols in the Asian diet. Several
in vitro studies and some in vivo studies, mainly in animals have shown that individual
spices, including turmeric (containing curcumin), cinnamon (cinnimic acid), ginger, garlic
etc. have been shown to improve glucose and lipid metabolism.However, well-controlled
randomised trials, within the normal dietary context in humans are limited.
This study will be conducted using a three-way randomised crossover design using the Latin
square approach. In the two treatment sessions, each volunteer will consume a mixed spice
dish at two doses (i.e., 'small portion' or 'large portion' curry sauce), and rice as the
base ingredient. In the control session, the same base ingredient (rice) but without the
mixed spices will be served. The total amount of mixed spices consumed, to be made from dried
powders of turmeric, cumin, coriander, gooseberry (amla), cinnamon, clove and cayenne pepper,
will be 6 g and 12 g for small and large portion curries respectively. In addition, as added
vegetables, the curry meals will contain tomato, garlic, onion and ginger, whereas the
control meal will just have tomato and peeled aubergine, although, the total amount of
vegetables will remain the same across all dishes (treatment or control).
The primary objective of this study will be to measure postprandial and fasting changes in
blood glucose, insulin, triglycerides (TG), free fatty acids (FFA), 24h ambulatory blood
pressure (BP), endothelial function and inflammatory markers following consumption of
increasing doses of mixed spices in a single meal, on separate occasions.
The secondary objective of the study will be to monitor changes in blood levels of gut
hormones, plasma and urine metabolome including polyphenols such as benzoate and hippurate,
gut microflora content and function, as a result of the mixed spice intake. A subset of the
treatments (control and high spice dose only) will also have interstitial glucose monitored
continuously for a period of up to 3 days using the continuous glucose monitoring system
(CGMS).
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03731013 -
Combining a Mediterranean Diet With Physical Activity to Address Cardiometabolic Risk
|
N/A | |
Completed |
NCT03839212 -
The Happy Older Latinos Are Active (HOLA) Health Promotion Study in HIV-Infected Latino Men
|
N/A | |
Completed |
NCT03773900 -
Characterization of Gut Microbiota Composition and Activity After a Daily Supplementation of 4.5 g/Day of ChitinGlucan Fibre During 3 Weeks in At-cardiometabolic Risk Volunteers
|
N/A | |
Completed |
NCT05771571 -
Investigation of the Acute Effect of Novel Olive Oil on Postprandial Oxidative Stress Biomarkers (BioliveCT)
|
N/A | |
Active, not recruiting |
NCT04902417 -
Dairy and Inflammation Study
|
N/A | |
Completed |
NCT03257085 -
CALIBER Phase 1: A Pilot Study in Normal-weight and Overweight Adults.
|
N/A | |
Completed |
NCT02099032 -
Milk Polar Lipids Consumption, Lipid Metabolism, and Inflammation in Menopausal Women
|
N/A | |
Completed |
NCT01467544 -
Reduce Cardiovascular Risk in Women Through Tai Chi Intervention
|
N/A | |
Completed |
NCT04011995 -
Effects of Intermittent Caloric Restriction in Youth With Cardiometabolic Risk
|
N/A | |
Completed |
NCT04190706 -
Synergistic Innovative Functional Food Concepts to Neutralize Inflammation for Cardiometabolic Risk Prevention
|
N/A | |
Completed |
NCT03274739 -
Maternal Diet, Body Mass Index Trajectories and Cardiometabolic Risk in Early Childhood
|
||
Recruiting |
NCT05400005 -
Impact of Different Types of Higher Dietary Protein Intake on Sleep Quality in Singapore Older Adults
|
N/A | |
Terminated |
NCT04737044 -
Effects of Antioxidant Sugar vs Granulated Sugar on Metabolic Outcomes in Healthy and Cardio Metabolic Subjects
|
N/A | |
Completed |
NCT05228925 -
GraviD-child Follow-up of the Children´s Health, Growth and Development Within the GraviD-study
|
||
Completed |
NCT04275440 -
Effects of Caloric Restriction and Exercise on Body Weight, Immune Function, and Intestinal Flora
|
N/A | |
Withdrawn |
NCT04359433 -
Intermittent Exercise Among Students
|
N/A | |
Completed |
NCT02146339 -
Impact of Milk Polar Lipids on Lipids Digestion, Absorption and Metabolism
|
N/A | |
Recruiting |
NCT04834687 -
Effects of Diet and Exercise Interventions on Cardiometabolic Risk Markers, Executive Function, and Intestinal Flora
|
N/A |