AiCR : Artificial Intelligence in Cardiac aRrest

Cardio Respiratory Arrest Clinical Trial

— AiCR  

Official title:

AiCR : Artificial Intelligence in Cardiac aRrest Application of an Algorithm in the Prognosis of Recovered Cardiorespiratory Arrests

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04462380
• Other study ID #: 20reamed01
• Status: Recruiting
• Start date: February 1, 2020
• Est. completion date: December 31, 2020

Study information

• Verified date: July 2020
• Source: Centre Hospitalier Universitaire de Nice
• Contact: Jean DELLAMONICA
• Phone: 33 4 920 35 510
• Email: dellamonica.j[@]chu-nice.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The overall incidence of cardiorespiratory arrest in Europe is estimated at 350,000 to 700,000 cases per year. Survival rate is estimated at 10.7% for all rhythm disorders combined.

Several examples of AI application in the medical field exist. Ting et al have developed a computer tool capable of diagnosing the presence of diabetic retinopathy with excellent power. In resuscitation, Celi et al proposed a tool capable of predicting the need for crystalloid vascular filling during a systemic inflammatory state. In Nature in 2018, Komorowski demonstrated the efficacy of AI in the hemodynamic management of sepsis. In a study of the renal response to fluid challenge, Zhang et al. demonstrate the effectiveness of the learning machine.

Objectives: Determination of an algorithm capable of predicting the mortality of patients admitted to intensive care units (ICU) for ACR from hospitalization reports (CRH). Also use of the algorithm to predict the risk of recurrence of the arrest, the duration of mechanical ventilation, the appearance of sepsis, the development of organ failure, prediction of the CPC (Cerebral Performance Category), time to obtain catecholamine withdrawal, the appearance of acute renal failure with or without the need for extra-renal purification (EER) and duration under EER, the average length of stay.

This project is part of a larger, nationwide project with greater power, and includes all the data generated during hospitalization in intensive care.

Method: an estimated total number of patients included in this study to be between 300 and 500. The population will come from the intensive care units of Nice, Antibes, Cannes, Grasse.

Inclusion will be retrospective, on CRH, CR of CT imaging (cerebral and thoraco-abdomino-pelvic), MRI, EEG, and daily follow-up words, from 2014 to the end of 2020.

After anonymisation, application of semantisation using natural language processing (NLP) methods. The data to be extracted are entered in a document written by intensive care physicians. These data will then be stored in a database. In order to meet the main objective, we will develop a computer algorithm capable of predicting mortality in the study population. This algorithm, based on a large database, can be designed using machine learning or even deep learning techniques depending on the amount of data to be processed.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 500
• Est. completion date: December 31, 2020
• Est. primary completion date: December 31, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• OCA recovered from: hypoxic, ischemic, pulmonary embolism, tamponade, rhythm or conduction disorder, shockable or not, intra or extra-hospital.

• CR computerized, typed in PDF format

Exclusion Criteria:

-

Related Conditions & MeSH terms

• Apnea
• Cardio Respiratory Arrest
• Heart Arrest

Locations

Country	Name	City	State
France	Nice Hospital	Nice

Sponsors (3)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Nice	AIINTENSE, Institut National de Recherche en Informatique et en Automatique

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Prediction of mortality in the intensive care unit	Definition of a semantic reporting tool, automated, transition from an anonymized report to an operational and relevant database.	1day
Primary	Prediction of mortality in the intensive care unit	Use of the database thus created to create an intelligent mortality prediction algorithm. Use also on secondary judgment criteria in order to predict other parameters mentioned below.	1day