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Damage and Renal Clearance of Glycocalyx in Cardiac Surgery — GlycoCarSur  

Cardio-Renal Syndrome Clinical Trial

Official title:
Damage and Renal Clearance of Glycocalyx in Cardiac Surgery

Clinical Trial Summary

The glycocalyx is a component of the vascular endothelium that currently plays a relevant role in the modified Starling theory.

The manipulation of the heart during cardiac surgery stimulates the release of the natriuretic atrial peptide, which causes endothelial wear in patients undergoing extracorporeal circulation. Dilation of the atrium produces natriuretic atrial peptide, which reduces plasma volume by increasing renal excretion and vascular permeability. The atrial peptide degrades the surface of the coronary endothelium, causing loss of the side cam protein nucleus. This study investigates the relationship between clamping time in cardiac surgery and the clearance of endothelial inflammation markers.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04332952
Study type Observational
Source Hospital Beneficencia Espanola de Puebla
Contact
Status Completed
Phase
Start date August 1, 2017
Completion date December 31, 2017
View Details
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